Nanosized peptide nucleic acid - metal complex hybrids as catalysts for the cleavage of phosphate ester bonds in biological molecules

纳米肽核酸-金属复合物杂化物作为生物分子中磷酸酯键断裂的催化剂

• 批准号: DP0343521
• 负责人: Prof Leone Spiccia
• 金额: $ 6.48万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0343521
• 关键词: Nanosized; peptide; nucleic; acid; metal

The information from Human Genome Project is being used to generate molecules with a variety of therapeutic and diagnostic applications. The capability to design, synthesise and manipulate functional molecules that mimic biological processes will underpin many emerging applications. In this project, macrocyclic metal complexes that catalyse the cleavage of phosphate ester bonds in biological molecules will be developed. Active complexes will be incorporated into nanosized peptide nucleic acid (PNA) - metal complex hybrids and applied as artificial enzymes in the sequence specific cleavage of RNA and DNA. Novel applications of these ?artificial enzymes? in biotechnology are anticipated.

来自人类基因组计划的信息正被用于产生具有各种治疗和诊断应用的分子。设计、合成和操纵模拟生物过程的功能分子的能力将支持许多新兴应用。在本项目中，将开发催化生物分子中磷酸酯键裂解的大环金属配合物。活性配合物将被纳入纳米肽核酸(PNA) -金属配合物杂合体中，并作为人工酶用于RNA和DNA的序列特异性切割。它们的新应用？人工酶吗?在生物技术领域。