Metal complex-aminoglycoside conjugates for sequence-specific cleavage of ribonucleic acid (RNA)

用于核糖核酸 (RNA) 序列特异性切割的金属复合物-氨基糖苷缀合物

• 批准号: DP1094100
• 负责人: Prof Leone Spiccia
• 金额: $ 31.35万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1094100
• 关键词: Metal; complex; aminoglycoside; conjugates; sequence

Ribonucleic acid (RNA) is emerging as an increasingly attractive drug target in the search for new approaches to combat diseases such as HIV/AIDS. This project will help position Australia at the forefront of research developments in the field of RNA-drug interactions, through the development of novel compounds that can cleave RNA molecules found in bacteria and retroviruses. In addition to a valuable body of knowledge that will assist in the future development of new drugs, this project will provide high quality multi-disciplinary training for young scientists keenly sought by emerging medical and biotechnological industries, research organisations and universities.

核糖核酸（RNA）正在成为一个越来越有吸引力的药物靶点，以寻找新的方法来对抗艾滋病毒/艾滋病等疾病。该项目将通过开发能够切割细菌和逆转录病毒中的RNA分子的新型化合物，帮助澳大利亚处于RNA-药物相互作用领域研究发展的最前沿。除了将有助于未来新药开发的宝贵知识之外，该项目还将为新兴医疗和生物技术行业，研究机构和大学迫切需要的年轻科学家提供高质量的多学科培训。