Metal complex-aminoglycoside conjugates for sequence-specific cleavage of ribonucleic acid (RNA)

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Ribonucleic acid (RNA) is emerging as an increasingly attractive drug target in the search for new approaches to combat diseases such as HIV/AIDS. This project will help position Australia at the forefront of research developments in the field of RNA-drug interactions, through the development of novel compounds that can cleave RNA molecules found in bacteria and retroviruses. In addition to a valuable body of knowledge that will assist in the future development of new drugs, this project will provide high quality multi-disciplinary training for young scientists keenly sought by emerging medical and biotechnological industries, research organisations and universities.