Identification of molecular targets to cure intractable neuropathic pain with nerve injury-induced demyelination
Identification of molecular targets to cure intractable neuropathic pain with nerve injury-induced demyelination
批准号:
17109015
负责人:
UEDA Hiroshi
金额:
$69.31万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
We successfully identified various molecular targets for medicines to cure neuropathic pain. They are related to the lysophospahtidic acid (LPA)-mediated mechanisms underlying injury-induced demyelination, gene regulation, microglia activation and supra-spinal pain. Feed-forward amplification of these mechanisms and epigenetic gene regulation of key pain-related molecules were suggested to underlie the chronic status of neuropathic pain.
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Circadian-dependent learning and memory enhancement in nociceptin receptor-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task
使用新型 KUROBOX 装置使用无压力正向提示任务增强伤害感受素受体缺陷小鼠的昼夜节律依赖性学习和记忆
DOI:
--
发表时间:
2007
期刊:
J Pharmacol Exp Ther. 321
影响因子:
--
作者:
[Fujita R, Kiguchi N, Ueda H., Misaki Matsumoto, Jun Nagai]
通讯作者:
Jun Nagai
Circadian-dependent learning and memory enhancement in nociceptin receptor (NOP)-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task.
使用无压力积极提示任务的新型 KUROBOX 装置增强伤害感受素受体 (NOP) 缺陷小鼠的昼夜节律依赖性学习和记忆。
DOI:
--
发表时间:
2007
期刊:
J Pharmacol Exp Ther (In press)
影响因子:
--
作者:
[Fujita R, Kiguchi N, Ueda H., Misaki Matsumoto, Jun Nagai, Mutsumi Ueda, 植田 弘師, 井上 誠, Fujita R, Nagai J]
通讯作者:
Nagai J
Neural pathological roles for receptor mediated LPA signaling
受体介导的 LPA 信号传导的神经病理作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Xie W, Uchida H, Nagai J, Ueda M, Chun J, Ueda H., 植田弘師, 植田弘師, 西依倫子, 西依倫子, 佐々木恵太, 内田仁司, 永井潤, 永井潤, 植田弘師, 松下洋輔, 井上 誠, 内田仁司, Ueda H]
通讯作者:
Ueda H
神経因性疼痛のAβ線維を介する過敏応答-脊髄後角における新たなERK1/2リン酸化の証明
神经性疼痛中 Aβ 纤维介导的超敏反应 - 脊髓背角中新型 ERK1/2 磷酸化的证据
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Xie W, Uchida H, Nagai J, Ueda M, Chun J, Ueda H., 植田弘師, 植田弘師, 西依倫子, 西依倫子, 佐々木恵太, 内田仁司, 永井潤, 永井潤, 植田弘師, 松下洋輔, 井上 誠, 内田仁司, Ueda H, 植田弘師, 植田弘師, 植田弘師, 澤智華, 西依倫子, 永井潤, 小川智世, 馬琳, 謝維嬌, 植村朋香, 内田仁司, 永井潤, 三浦裕, Makoto Inoue, Yousuke Matsushita, 藤田亮介, Hiroshi Ueda, Miroshi Ueda, Hiroshi Ueda, 植田弘師, Misaki Matsumoto, Hiroshi Ueda, 植田弘師, Lin Ma, Weijiao Xie, Misaki Matsumoto, Saori Yonekubo, Michiko Horiguchi, Jun Nagai, Lin Ma, Weijiao Xie, Hiroshi Ueda, 植田弘師, Ueda H, 植田弘師, Hiroshi Ueda, 植田 弘師, 松本 みさき]
通讯作者:
松本 みさき
Evidence for Aβ-fiber-mediated allodynia; novel appearance of pERK in spinal dorsal horn
Aβ 纤维介导的异常性疼痛的证据;脊髓背角中 pERK 的新出现
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Xie W, Uchida H, Nagai J, Ueda M, Chun J, Ueda H., 植田弘師, 植田弘師, 西依倫子, 西依倫子, 佐々木恵太, 内田仁司, 永井潤, 永井潤, 植田弘師, 松下洋輔, 井上 誠, 内田仁司, Ueda H, 植田弘師, 植田弘師, 植田弘師, 澤智華, 西依倫子, 永井潤, 小川智世, 馬琳, 謝維嬌, 植村朋香, 内田仁司, 永井潤, 三浦裕, Makoto Inoue, Yousuke Matsushita, 藤田亮介, Hiroshi Ueda, Miroshi Ueda, Hiroshi Ueda, 植田弘師, Misaki Matsumoto, Hiroshi Ueda, 植田弘師, Lin Ma, Weijiao Xie, Misaki Matsumoto, Saori Yonekubo, Michiko Horiguchi, Jun Nagai, Lin Ma, Weijiao Xie, Hiroshi Ueda, 植田弘師, Ueda H, 植田弘師, Hiroshi Ueda, 植田 弘師, 松本 みさき, 松下 洋輔, 植田 弘師, Misaki Matsumoto, Lin Ma, Weijiao Xie]
通讯作者:
Weijiao Xie
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Innate immunity regulation by prothymosin alpha -mimetics
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Species-specific ecology of the carnivorous zooplankton Poecilostomatoida and Chaetognatha
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Novel Expansion of Bioanalysis Based on the Fluorescence Quench-Release Principle
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Comprehensive clinical application of new oral appliance for obstructive sleep apnea
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Construction of versatile fluoroimmunoassay probe based on quench-release principle
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High Accuracy Computation for Design of Hight Temperature Superconducting Magnet using Multiscale Electromagentic Analysis
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Screening of binary neuroprotective DAMPs activity
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The physiological roles of the phosphorylation of heterotrimeric G protein signal-dependent RhoGEFs
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Clinical application of a new oral appliance to diminish dental/occlusal side effects in the treatment for obstructive sleep apnea
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3D numerical method for evaluation of superconducting applications
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