Identification of molecular targets to cure intractable neuropathic pain with nerve injury-induced demyelination
Identification of molecular targets to cure intractable neuropathic pain with nerve injury-induced demyelination
批准号:
17109015
负责人:
UEDA Hiroshi
金额:
$69.31万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
We successfully identified various molecular targets for medicines to cure neuropathic pain. They are related to the lysophospahtidic acid (LPA)-mediated mechanisms underlying injury-induced demyelination, gene regulation, microglia activation and supra-spinal pain. Feed-forward amplification of these mechanisms and epigenetic gene regulation of key pain-related molecules were suggested to underlie the chronic status of neuropathic pain.
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オピオイド耐性機構に関与するグルタミン酸-NMDA受容体アンチオピオイド機構
谷氨酸-NMDA受体抗阿片机制参与阿片耐受机制
DOI:
--
发表时间:
2009
期刊:
麻酔 58
影响因子:
--
作者:
[Uchida H, Matsumoto M, Ueda H., Yosuke Matsushita, Hitoshi Uchida, Lin Ma, Lin Ma, 植田弘師]
通讯作者:
植田弘師
神経障害性疼痛を担うフィードフォワード増幅機構
导致神经性疼痛的前馈放大机制
DOI:
--
发表时间:
2009
期刊:
ペインクリニック 30
影响因子:
--
作者:
[Uchida H, Matsumoto M, Ueda H., Yosuke Matsushita, Hitoshi Uchida, Lin Ma, Lin Ma, 植田弘師, 植田弘師, 植田弘師]
通讯作者:
植田弘師
Circadian-dependent learning and memory enhancement in nociceptin receptor-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task
使用新型 KUROBOX 装置使用无压力正向提示任务增强伤害感受素受体缺陷小鼠的昼夜节律依赖性学习和记忆
DOI:
--
发表时间:
2007
期刊:
J Pharmacol Exp Ther. 321
影响因子:
--
作者:
[Fujita R, Kiguchi N, Ueda H., Misaki Matsumoto, Jun Nagai]
通讯作者:
Jun Nagai
Circadian-dependent learning and memory enhancement in nociceptin receptor (NOP)-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task.
使用无压力积极提示任务的新型 KUROBOX 装置增强伤害感受素受体 (NOP) 缺陷小鼠的昼夜节律依赖性学习和记忆。
DOI:
--
发表时间:
2007
期刊:
J Pharmacol Exp Ther (In press)
影响因子:
--
作者:
[Fujita R, Kiguchi N, Ueda H., Misaki Matsumoto, Jun Nagai, Mutsumi Ueda, 植田 弘師, 井上 誠, Fujita R, Nagai J]
通讯作者:
Nagai J
Neural pathological roles for receptor mediated LPA signaling
受体介导的 LPA 信号传导的神经病理作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Xie W, Uchida H, Nagai J, Ueda M, Chun J, Ueda H., 植田弘師, 植田弘師, 西依倫子, 西依倫子, 佐々木恵太, 内田仁司, 永井潤, 永井潤, 植田弘師, 松下洋輔, 井上 誠, 内田仁司, Ueda H]
通讯作者:
Ueda H
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