Screening of binary neuroprotective DAMPs activity

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Prothymosin a (ProTa), a nuclear protein plays multi-functional roles in the nucleus, cytosol, and extracellular environment in terms of auto-protection. We have already revealed that ProTa is released from neurons on ischemic stress through non-vesicular manner and exerts a unique form of neuroprotection through an anti-necrotic mechanism. In addition, extracellular ProTa also exerts an anti-apoptosis through neuroimmunological system. Regarding manner of stress-induced release, ProTa is categorized as novel neuroprotective damage-associated molecular patterns (DAMPs). The extracellular role of ProTa against ischemia-induced damages is mediated through different two plasma membrane receptors. In the present study, we revealed mechanism of ProTa for the neuroprotection via these receptors. Furthermore, we successfully identified functional domains of ProTa as a peptide level on receptor, a candidate druggable target in the treatment of brain infarct.