Development of irradiation field for neutron capture therapy using direct neutrons from compact proton accelerator

利用紧凑型质子加速器直接中子开发中子俘获治疗照射场

基本信息

批准号：
17300172
负责人：
KOBAYASHI Tooru
金额：
$ 7.8万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17300172/
关键词：
Neutron capture therapy Compact proton accelerator Direct neutron Irradiation system 7Li(p.n)7Be reaction Backing material TPD method BDE method 7Li (p, n) 7Be反応 BNCT 中性子発生ターゲットリチウムターゲットバッキング材陽子エネルギー

项目摘要

We examined the characteristics of the target assembly for the direct usage of near threshold^7L i(p,n)^7Be neutrons for BNCT. We were able to clarify the following :1) We performed a parametric survey, via simulation, of the dependence of the characteristics of the BNCT irradiation field on the thickness of the lithium target. Neutron and gamma ray fluxes were determined in order to verify the usability of the irradiation fields for BNCT. We also investigated the influence of incident proton energy on the irradiation field by considering energies between 1.89MeV to 1.92MeV. The evaluation indices applied were the treatable protocol depth (TPD) and boron-dose enhancer (BDE) thickness.2) Regarding gamma ray production in the target assembly, our experiment at the HIRRAC in Hiroshima University showed that tungsten and molybdenum were better than copper and aluminum as backing materials at the proton energy of 1.9MeV. During the same experiment, solid Li with thickness of 10μm deposited … More on a W plate had exfoliated after several hours of irradiation at 150μA. It was therefore judged that solid Li is not suitable for practical use from the viewpoint of target life-time. Based on this result, we performed fundamental experiments on the potential use of thin film liquid Li target simulated by water flow formation. We confirmed that practical liquid film will be possible for a thickness of 1mm at 50mm in width and 50mm in length and a flow rate of 30m/s generated from a linear array of nozzles and flowing against a guide plate.3) The liquid Li-metal flow experiment (2005) in the IFMIF project and the remarkable achievement of the group of ANL suggested that liquid Li thin film formation is technically possible and the prospect of its practical implementation is high.As to the neutrons from the near threshold^7Li (p,n) ^7Be reaction, we are going to continue to develop a BNCT irradiation field, and will push for the future implementation of accelerator BNCT irradiation system. Less

我们检查了目标组件的特征，以直接使用接近阈值^7l I（p，n）^7BE BNCT的中性。我们能够阐明以下内容：1）我们通过模拟进行了参数调查，该调查对BNCT辐射场特征的依赖性对锂靶标的厚度进行了调查。确定中子和伽马射线通量，以验证BNCT辐射场的可用性。我们还通过考虑1.89mev至1.92mev之间的能量来研究入射质子能量对辐射场的影响。应用的评估指标是针对目标组装中伽马射线产生的治疗方案深度（TPD）和硼剂量增强剂（BDE）厚度。2）我们在广岛大学的Hirrac进行的实验表明，钨和钼比铜和铝材料优于Proton proton Energy proton of proton of proton of proton of proton of proton of proton of proton of 1.9ms 1.9ms 1.9mev。在同一实验中，沉积为10μm的固体LI…在150μa下进行了数小时的照射后，W板上的更多内容已被去除。因此，从目标寿命的角度来看，固体LI不适合实际使用。基于此结果，我们对通过水流形成模拟的薄膜液体LI目标的潜在使用进行了基本实验。我们证实，实用的液体膜将有可能在50mm的宽度和50mm的厚度和长度50mm的厚度和30m/s的流速和30m/s的流量中产生，从线性阵列和向导板上流动。对于接近阈值 ^7li（p，n） ^7be反应的中子，我们将继续发展一个BNCT辐射场，并将推动未来的Accelerator BNCT辐照系统的实施。较少的