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Development of irradiation field for neutron capture therapy using direct neutrons from compact proton accelerator

利用紧凑型质子加速器直接中子开发中子俘获治疗照射场

基本信息

批准号：
17300172
负责人：
KOBAYASHI Tooru
金额：
$ 7.8万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17300172/
关键词：
Neutron capture therapy Compact proton accelerator Direct neutron Irradiation system 7Li(p.n)7Be reaction Backing material TPD method BDE method 7Li (p, n) 7Be反応 BNCT 中性子発生ターゲットリチウムターゲットバッキング材陽子エネルギー

项目摘要

We examined the characteristics of the target assembly for the direct usage of near threshold^7L i(p,n)^7Be neutrons for BNCT. We were able to clarify the following :1) We performed a parametric survey, via simulation, of the dependence of the characteristics of the BNCT irradiation field on the thickness of the lithium target. Neutron and gamma ray fluxes were determined in order to verify the usability of the irradiation fields for BNCT. We also investigated the influence of incident proton energy on the irradiation field by considering energies between 1.89MeV to 1.92MeV. The evaluation indices applied were the treatable protocol depth (TPD) and boron-dose enhancer (BDE) thickness.2) Regarding gamma ray production in the target assembly, our experiment at the HIRRAC in Hiroshima University showed that tungsten and molybdenum were better than copper and aluminum as backing materials at the proton energy of 1.9MeV. During the same experiment, solid Li with thickness of 10μm deposited … More on a W plate had exfoliated after several hours of irradiation at 150μA. It was therefore judged that solid Li is not suitable for practical use from the viewpoint of target life-time. Based on this result, we performed fundamental experiments on the potential use of thin film liquid Li target simulated by water flow formation. We confirmed that practical liquid film will be possible for a thickness of 1mm at 50mm in width and 50mm in length and a flow rate of 30m/s generated from a linear array of nozzles and flowing against a guide plate.3) The liquid Li-metal flow experiment (2005) in the IFMIF project and the remarkable achievement of the group of ANL suggested that liquid Li thin film formation is technically possible and the prospect of its practical implementation is high.As to the neutrons from the near threshold^7Li (p,n) ^7Be reaction, we are going to continue to develop a BNCT irradiation field, and will push for the future implementation of accelerator BNCT irradiation system. Less

我们研究了用于BNCT的直接使用近阈值^7I(p，n)^7Be中子的靶组件的特性。我们能够澄清以下几点：1)通过模拟，我们对BNCT辐射场特性与锂靶厚度的关系进行了参数测量。为了验证BNCT辐射场的可用性，测量了中子和伽马射线通量。考虑能量在1.89 MeV到1.92 MeV之间，我们还研究了入射质子能量对辐射场的影响。应用的评估指标是可治疗方案深度(TPD)和硼剂量增强剂(BDE)厚度。2)关于靶组件中的伽马射线产生，我们在广岛大学HIRRAC进行的实验表明，在1.9 MeV的质子能量下，钨和钼作为衬底材料比铜和铝更好。在同一实验中，厚度为10μm的固体Li沉积了…在150μA辐照数小时后，W板上有更多的Li被剥落，因此从靶材寿命的角度判断固体Li不适合实际使用。在此基础上，我们对模拟水流形成的薄膜液态锂靶材的潜在用途进行了基础性实验。我们证实了厚度为1 mm、宽50 mm、长50 mm、流量为30m/S的实际液膜是可能的。3)2005年在IFMIF项目中的液态Li-金属流动实验和ANL小组的显著成果表明，液态Li薄膜的形成在技术上是可能的，其实际应用前景很高。对于接近阈值的中子~7Li(p，n)^7Be反应，我们将继续开发BNCT辐照场，并将推动未来加速器BNCT辐照系统的实施。较少