Surface modification for Bio-Metallic Materials for Prevention of Harmful ion Dissolution under Dynamic loading

用于防止动态负载下有害离子溶解的生物金属材料的表面改性

• 批准号: 17360342
• 负责人: FUJIMOTO Shinji
• 金额: $ 9.92万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17360342/
• 关键词: Bio Materials; Ni-Ti alloys; Bio compatibility; passive films; repassivation; Martensitic transformation; cell adhesives; shape memory effect; チタン合金; 模擬生体環境; 皮膜破壊; 急速ひずみ電極

The bio compatibility of metallic biomaterials are characterized electrochemically using conventional polarization measurements under cell culturing condition, a rapid straining electrode technique. The surface modification of metallic materials including stainless steels, Ni-Ti alloy, Ti and its alloys with oxide formation and also electroconductive polymers.The electrochemical corrosion behavior of Type 304 and 316L stainless steels was studied in Hanks' solution, Eagle's Minimum Essential Medium (MEM), serum containing medium (MEM with 10% of fetal bovine serum) without cells, and serum containing medium with cells over a one-week period. Polarization resistance measurements indicated that the stainless steels were resistant to Hanks' and MEM solutions. Type 304 was more inferior to pitting corrosion than Type 316L in Hanks' and MEM solutions. The uniform corrosion resistance of stainless steels, determined by R_p, was lower in culturing medium than in Hanks' and MEM. The low corros … More ion resistance was due to surface passive film with less protective to reveal high anodic dissolution rate. When cells were present, the initial corrosion resistance was low; but gradually increased after three days, consistent with the trend of cell coverage. The presence of cell was found to suppress the cathodic reaction, that is, oxygen reduction, and increase the uniform corrosion resistance as a consequence. On the other hand, both Type 304 and 316L stainless steels become more susceptible to pitting corrosion when they were covered with cells.Ti and Ti based alloys are characterized by a continuous electrochemical monitoring and a rapid straining electrode technique in simulated body fluid environment. Materials examined are Ti, Ti-6AI-7Nb, Ti-6AI-4V and Ti-29Nb-13Ta-4.6Zr. Sterilized specimens were immersed in Hanks solution or Eagle's minimum essential medium (MEM) solution. Electrode potential and polarization resistance were simultaneously and continuously measured up to 7 days. For all the specimens examined, the corrosion potential reached to a steady state in 2 days for both solutions. On the other hand, corrosion resistance increased monotonously for the period examined. Less

利用细胞培养条件下的常规极化测量方法--快速应变电极技术，对金属生物材料的生物相容性进行了电化学表征。研究了不锈钢、镍钛合金、钛及其合金表面形成氧化物和导电聚合物的表面改性。研究了304和316L不锈钢在Hanks‘s溶液、Eagle最小基本介质(MEM)、无细胞血清(MEM+10%胎牛血清)和含细胞血清介质中一周的电化学腐蚀行为。极化电阻测试表明，这些不锈钢对Hanks‘s溶液和MEM溶液都有很好的耐受性。在Hanks‘s和MEM溶液中，304比316L更不利于点蚀。由Rp测定的不锈钢在培养介质中的均匀耐蚀性低于Hanks‘s和MEM。低科罗斯…表面钝化膜的保护性较差，表现出较高的阳极溶解速率，从而产生较大的离子阻力。当有电池存在时，初始耐蚀性较低；但在三天后逐渐增加，与电池覆盖率的趋势一致。电池的存在抑制了阴极反应，即氧的还原，从而提高了均匀的耐蚀性。另一方面，304和316L不锈钢在被电池覆盖时都更容易发生点蚀。钛和钛基合金在模拟体液环境中具有连续电化学监测和快速应变电极技术的特点。试验材料为钛、钛-6Al-7Nb、钛-6Al-4V和钛-29Nb-13Ta-4.6Zr。将灭菌标本浸泡在Hanks液或Eagle‘s最低基本培养液(MEM)中。同时连续测量电极电位和极化电阻，最长达7天。对于所有被检查的样品，两种溶液的腐蚀电位在2天内达到稳定状态。另一方面，在所研究的时间段内，耐蚀性单调地增加。较少

项目成果

Improvement of cell adhesion on poly(L-lactide) by atmospheric plasma treatment

• DOI: 10.1002/jbm.a.30521
• 发表时间: 2006-04-01
• 期刊: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
• 影响因子: 4.9
• 作者: Nakagawa, M;Teraoka, F;Takahashi, J
• 通讯作者: Takahashi, J

Electrochemical-Alkali Treatment on Ti29Nb13Ta4.6Zr Alloy for Hydroxyapatite Growth

Ti29Nb13Ta4.6Zr 合金电化学碱处理促进羟基磷灰石生长

• 发表时间: 2006
• 作者: Vedarajan;Raman;Yee-Chin;Tang;Nallaiyan;Rajendran;Shinji;Fujimoto
• 通讯作者: Fujimoto

Semiconductor properties and protective role of passive films of iron base alloys

• DOI: 10.1016/j.corsci.2006.05.020
• 发表时间: 2007-01-01
• 期刊: CORROSION SCIENCE
• 影响因子: 8.3
• 作者: Fujimoto, Shinji;Tsuchiya, Hiroaki
• 通讯作者: Tsuchiya, Hiroaki