Surface modification for Bio-Metallic Materials for Prevention of Harmful ion Dissolution under Dynamic loading

采用快速应变电极技术，在细胞培养条件下，用电化学方法对金属生物材料的生物相容性进行了表征。研究了不锈钢、Ni-Ti合金、钛及其合金表面氧化改性以及聚合物表面改性后304和316L不锈钢在Hanks溶液、Eagle最小必需培养基（MEM）、含血清介质中的电化学腐蚀行为（含10%胎牛血清的MEM）和含细胞的含血清培养基培养一周。极化电阻测量表明，不锈钢耐Hanks和MEM溶液。在Hanks和MEM溶液中，304型比316 L型更容易发生点蚀。用R_p法测定不锈钢在培养基中的均匀腐蚀抗力低于在Hanks和MEM中的均匀腐蚀抗力， ...更多信息 离子电阻是由于表面钝化膜保护性较差，显示出较高的阳极溶解速率。当电池存在时，初始耐腐蚀性较低;但在三天后逐渐增加，与电池覆盖的趋势一致。发现电池的存在抑制了阴极反应，即氧还原，并因此提高了均匀耐腐蚀性。在模拟体液环境中，采用连续电化学监测和快速应变电极技术，研究了钛和钛基合金在模拟体液环境中的腐蚀行为。检查的材料为Ti、Ti-6Al-7 Nb、Ti-6Al-4V和Ti-29 Nb-13 Ta-4.6Zr。将无菌标本浸入Hanks溶液或Eagle最小必需培养基（MEM）溶液中。电极电位和极化电阻同时和连续测量长达7天。两种溶液的腐蚀电位均在2天内达到稳定。另一方面，耐腐蚀性单调增加的时期检查。少

The bio compatibility of metallic biomaterials are characterized electrochemically using conventional polarization measurements under cell culturing condition, a rapid straining electrode technique. The surface modification of metallic materials including stainless steels, Ni-Ti alloy, Ti and its alloys with oxide formation and also electroconductive polymers.The electrochemical corrosion behavior of Type 304 and 316L stainless steels was studied in Hanks' solution, Eagle's Minimum Essential Medium (MEM), serum containing medium (MEM with 10% of fetal bovine serum) without cells, and serum containing medium with cells over a one-week period. Polarization resistance measurements indicated that the stainless steels were resistant to Hanks' and MEM solutions. Type 304 was more inferior to pitting corrosion than Type 316L in Hanks' and MEM solutions. The uniform corrosion resistance of stainless steels, determined by R_p, was lower in culturing medium than in Hanks' and MEM. The low corros … More ion resistance was due to surface passive film with less protective to reveal high anodic dissolution rate. When cells were present, the initial corrosion resistance was low; but gradually increased after three days, consistent with the trend of cell coverage. The presence of cell was found to suppress the cathodic reaction, that is, oxygen reduction, and increase the uniform corrosion resistance as a consequence. On the other hand, both Type 304 and 316L stainless steels become more susceptible to pitting corrosion when they were covered with cells.Ti and Ti based alloys are characterized by a continuous electrochemical monitoring and a rapid straining electrode technique in simulated body fluid environment. Materials examined are Ti, Ti-6AI-7Nb, Ti-6AI-4V and Ti-29Nb-13Ta-4.6Zr. Sterilized specimens were immersed in Hanks solution or Eagle's minimum essential medium (MEM) solution. Electrode potential and polarization resistance were simultaneously and continuously measured up to 7 days. For all the specimens examined, the corrosion potential reached to a steady state in 2 days for both solutions. On the other hand, corrosion resistance increased monotonously for the period examined. Less