Development of a gas-scintillator detector and measurements of medical nuclear data at HIMAC

粒子放射治疗是各种癌症最有效的治疗方法之一，因为它提供了治愈具有高QOL的严重癌症的高可能性。为了有效地抑制副作用，需要开发基于精确估计辐射剂量的先进治疗计划方法。核碎片在DNA破坏中起着关键作用，因此核数据是实现剂量估算系统的重要数据。由于测量这些具有非常高的线性能量转移的数据存在困难，因此有必要开发新的检测器系统。因此，我们研制了一种闪烁体探测器系统，并将其应用于HIMAC、NIRS的核数据测量。在HIMAC、NIRS等实验室进行了大量的实验，并对碎片中的多种核素进行了测量。同步加速器HIMAC提供高能C-12离子束，轰击C-12靶。用气体闪烁检测器检测反应中发射的带电粒子。最后，我们确定了质子生产的双微分截面在大多数前向角0至3度，测量是非常困难的一般。测量质子的能量范围为200至500 MeV。此外，我们进行了几次测量检测器测试，以允许能量校准。其中之一是俄罗斯JINR测量晶体对质子和其他粒子的响应。这些数据表明了一个重要的建议，即Birks处理的限制，以及进一步的分析应基于迈耶-默里通用曲线方法。为了更深入地了解，需要采取进一步的微观办法。

Particulate radiation therapy is one of the most effective treatments for variety of cancers, because it offers a high possibility to cure serious cancer with high QOL To suppress side effects effectively, it is required to develop a method of advanced treatment planning based on accurate estimate of radiation dose. Nuclear fragments play a key role in destructing DNA, hence nuclear data are important quantity to realize the dose estimation system. Since there are difficulties in measuring these data, which have a very high linear energy transfers, it is necessary to develop a new detector system. Therefore, we developed a scintillator detector system and applied it to nuclear data measurements at HIMAC, NIRS. Extensive efforts were devoted to measure more nuclides of fragments.Experiments were carried out at HIMAC, NIRS. The synchrotron HIMAC provided high-energy C-12 ion beams, which bombarded a C-12 target. Emitted charged particles from reactions were detected with the gas-scintillation detector. Finally, we determined proton production double-differential cross sections at most forward angles zero to three degrees where measurements are very difficult in general. The energy range of measured protons was from 200 to 500 MeV.In addition, we carried out several measurements for detector test to allow energy calibrations. One was the measurements of crystal response to protons and other particles, which was made at JINR, Russia. The data show an important suggestion that the limit of the Birks treatment, and further analyses should be based on the Mayer-Murray universal curve approach. Further microscopic approach would be needed for deeper understanding.