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Characteristics of emotional related cognitive function in schizophrenia evaluating by exploratory eye movements and fMRI : comparison with healthy subjects.

通过探索性眼球运动和功能磁共振成像评估精神分裂症情绪相关认知功能的特征：与健康受试者的比较。

基本信息

批准号：
17390322
负责人：
MAEDA Hisao
金额：
$ 5.57万
依托单位：
Kurume University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390322/
关键词：
Brain and nerve Neuroscience

项目摘要

Exploratory eye movements (EEMs) have been used as a tool to investigate biological correlates of information processing. So far, little is known about the effect of facial-affect on EEMs in schizophrenic patients. Schizophrenic patients have been shown to manifest a significant deficit in the ability to correctly identify the emotions associated with facial expressions. Such patients have a distinctive deficit in emotional appropriateness, and an impaired ability to correctly identify facial affect might contribute to this deficit. The present study compared the effects of facial affective stimuli on EEMs and functional MRI (fMRI) in schizophrenic patients and age-matched healthy subjects using a crying baby and a smiling baby. Using the exploratory eye movements, both the total eye scanning length when viewing a smiling baby under comparison condition was longer than that when viewing a crying for healthy subjects but, the TESL when viewing a smiling baby was shorter that that when viewing a crying baby for patients. Both the total number of eye gaze points (TNGP) and reactive searching scores (RSS) for the smiling baby were larger than those for the crying baby in healthy subjects but, both the TNGP and RSS for the smiling baby were smaller than those for the crying baby in patients. Activation of fMRI around amygdara area was observed when viewing the crying baby, but not when viewing the smiling baby under comparison condition in healthy subjects. However, activated amygdara area was recorded for the smiling baby but not for the crying baby under comparison condition in patients. These observations indicate that exploratory eye movements (EEMs) and fMRI were useful tools to evaluate emotional cognitive impairments in schizophrenic patients. Patients may cause mismatch the emotional process, especially positive emotion caused by the positive affection such as smiling.

探索性眼动（EEMs）已被用作研究信息处理的生物相关性的工具。到目前为止，面部情感对精神分裂症患者EEMs的影响知之甚少。精神分裂症患者在正确识别与面部表情相关的情绪方面表现出明显的缺陷。这类患者在情感适当性方面存在明显缺陷，正确识别面部情感的能力受损可能会导致这种缺陷。本研究比较了面部情感刺激对精神分裂症患者和年龄匹配的健康受试者的EEMs和功能磁共振成像（fMRI）的影响，使用一个哭泣的婴儿和一个微笑的婴儿。在探索性眼动条件下，健康受试者观察微笑婴儿时的眼动总长度大于观察哭泣婴儿时的眼动总长度，而患者观察微笑婴儿时的TESL小于观察哭泣婴儿时的TESL。健康婴儿中微笑婴儿的眼球注视点总数（TNGP）和反应性搜索得分（RSS）均大于哭泣婴儿，而患者中微笑婴儿的TNGP和RSS均小于哭泣婴儿。在健康受试者中，当观察哭泣的婴儿时，杏仁核区周围的fMRI被激活，但在对照条件下观察微笑的婴儿时则没有激活。然而，在对照条件下，微笑的婴儿记录到激活的杏仁核区域，而哭泣的婴儿则没有。这些观察结果表明，探索性眼球运动（EEMs）和功能磁共振成像是有用的工具，以评估精神分裂症患者的情绪认知障碍。患者可能会造成情感过程的不匹配，特别是由微笑等积极情感引起的积极情感。