Effect of polyphenol-containing azuki bean extract on blood pressure and stroke in an experimental model of hypertension

含多酚小豆提取物对高血压实验模型血压和中风的影响

• 批准号: 17500545
• 负责人: SATO Shin
• 金额: $ 2.36万
• 依托单位: Aomori University of Health and Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17500545/
• 关键词: Food; Azuki polyphenol; Hypertension; Stroke; Nitric oxide; Nitric oxide synthase; Macrophage; 栄養学; 小豆; 小豆抽出物; ポリフェノール; 高血圧; 腎臓; 自然発症高血圧ラット

Hypertension is known to be a major risk factor for myocardial infarction, stroke, and renal damage, and has also been shown to have proinflammatory actions, which increase the formation of reactive oxygen species such as superoxide (O_2-). In addition, infiltration by immunocompetent cells such as macrophages is thought to play a role in the pathogenesis of hypertension. Although the azuki bean (Vigna angularis) is known to be one of the most important crops, little is known about the beneficial effects of a diet of azuki beans on the progression of hypertension.In the present study, we investigated the effect of treatments of azuki beans extract (ABE) containing polyphenols with radical scavenging activities on high blood pressure in a rat model with hypertension, and whether the ABE affects O_2 production and macrophages infiltration in the aorta and kidney in chronic hypertension. Experiment 1 : Stroke-prone spontaneously hypertensive rats (SHRSP) were fed 0% and 0.9% ABE-containin … More g diets. Tail systolic blood pressure (SBP) and O_2 production in the aorta and kidney were examined. The elevation of SBP in the ABE-treated SHRSP was not suppressed compared with the untreated SHRSP. On the other hand, The NADPH-stimulated O_2 levels in the ABE-treated SHR was decreased significantly, compared with the untreated SHR. Experiment Z Spontaneously hypertensive rats (SHR) and control normotensive Wistar Kyoto rats (WKY) were fed 0% and 0.8% ABE-containing diets, respectively. Tail SBP and macrophage kinetics in the heart and kidney were examined. After 8 weeks of ABE treatment, the elevation of SBP in the ABE-treated SHR was significantly suppressed compared with the untreated SHR. In the immunohistochemical analyses, the number of macrophages in the heart and kidney in the ABE-treated SHR showed a significant decrease in number compared with the untreated SHR.In conclusion, these results suggested that ABE attenuated the elevation of SBP, O_2 production and macrophage infiltration of this SHR model. Less

高血压是心肌梗死、脑卒中和肾损害的主要危险因素，高血压还具有促炎作用，可增加超氧化物（O_2-）等活性氧的生成。此外，免疫活性细胞如巨噬细胞的浸润被认为在高血压的发病机制中起作用。虽然红豆红豆（Vigna angularis）是一种重要的粮食作物，但红豆对高血压的防治作用尚不清楚，本研究采用高血压大鼠模型，研究了红豆提取物（ABE）对高血压的治疗作用，ABE是否影响慢性高血压大鼠主动脉和肾脏的O_2生成和巨噬细胞浸润。实验一：易中风的自发性高血压大鼠（SHRSP）分别饲喂含0%和0.9% ABE的饲料 ...更多信息 g饮食。测定尾动脉收缩压（SBP）和主动脉、肾组织的O_2生成量。ABE处理组的SBP升高与未处理组相比没有受到抑制。另一方面，ABE处理的SHR，NADPH刺激的O_2水平较未处理的SHR明显降低。实验Z分别给自发性高血压大鼠（SHR）和正常血压Wistar京都大鼠（WKY）喂含0%和0.8% ABE的饲料。检查心脏和肾脏中的尾部SBP和巨噬细胞动力学。ABE治疗8周后，ABE治疗组SHR的SBP升高较未治疗组明显降低。免疫组化结果显示，ABE处理后SHR心脏和肾脏巨噬细胞数量明显减少，提示ABE可降低SHR收缩压、氧产生和巨噬细胞浸润。少

项目成果

On a relation between a change by aging and the Japanese Health Practice Index (JHPI)(Japanese)

论老龄化变化与日本健康实践指数（JHPI）之间的关系（日语）

• 发表时间: 2008
• 期刊: Journal of Japan Academy of Human Care Science. 1
• 作者: Yamada;M.;Komada;A.;Morinaga;Y.;Izawa;H.;Sato;S.;Sagai;M
• 通讯作者: M

ナガイモ投与の自然発症高血圧ラットの血圧上昇抑制に及ぼす影響

山药给药对抑制自发性高血压大鼠血压升高的作用

• 发表时间: 2005
• 期刊: 青森県立保健大学雑誌 6
• 作者: 野澤 めぐみ;佐藤 伸;羽鳥 有香;井澤 弘美;嵯峨井 勝
• 通讯作者: 嵯峨井 勝

栄養素等摂取量と脳卒中のリスクファクターとの関連に関する研究.

营养素摄入量与脑卒中危险因素关系的研究

• 发表时间: 2008
• 作者: 駒田亜衣,山田真司;森永八江;井澤弘美;佐藤 伸;嵯峨井勝
• 通讯作者: 嵯峨井勝

Effect of azuki beans extract on hypertension and nitric oxide production in spontaneously hypertensive rats. (Japanese)

小豆提取物对自发性高血压大鼠高血压和一氧化氮产生的影响。

• 发表时间: 2007
• 作者: Y. Mukai;A. Hatai;J. Kato;S. Sato
• 通讯作者: S. Sato

Effect of azuki bean extract on macrophage infiltration in the heart and kidney in spontaneously hypertensive rats. (Japanese)

小豆提取物对自发性高血压大鼠心脏和肾脏巨噬细胞浸润的影响。

• 发表时间: 2006
• 作者: S. Sato;Y. Hori;J. Yamate;J. Kato;A. Hatai;M. Sagai
• 通讯作者: M. Sagai