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Assessment of sensitive obesity animal models for dietary manipulation and investigation of dietary components with anti-obesity effects

用于饮食控制的敏感肥胖动物模型的评估以及具有抗肥胖作用的饮食成分的研究

基本信息

批准号：
17500549
负责人：
AOE Seiichiro
金额：
$ 1.73万
依托单位：
Otsuma Women's University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17500549/
关键词：
C57BL 6J mice KK Ta mice ob + mice db STR ort mice adipocyte abdominal fat 脂肪組織腹腔内組織レプチンレプチン受容体 Ortマウス

项目摘要

1. Diet induced response in C57BL/6J mice (a wild type ; +/+) : I examined the diet induced response in the wild type (+1+) mice for the purpose of collecting the background data of the ob hetero type mice (ob/+). As a result, in wild type mice (+1+), the high fat diet increased abdominal fat accumulation, but it was thought that the function of adipose tissues was not influenced significantly.2. Comparison of diet induced response between ob hetero type of the leptin knockout mice (ob/+) and the wild type mice (+/+) : As a result of comparison of the diet induced response between ob/+ and +/+ male mice, both mice models were observed diet induced response sensitively. These results suggested that influence of the high fat diet was stronger than the genotype in this mouse model.3. Evaluation of the functional food ingredients in hetero type (ob/+) and wild type (+/+) mice : As a result, inhibitory effect of the enlargement of the abdominal adipocyte was observed in the both of soy bean … More phospholipids and egg yolk phospholipids evaluated.4. Comparison of diet induced response between db hetero type of the leptin receptor knockout mice (db/+) and the wild type mice (+/+) : I bred the db/+ mice with a background of C57BL/6J mice with a mating method and compared the diet induced response. As a result, a difference between db/+ and +/+ mice was significant, and the marked difference was observed in the high fat diet compared to that in the normal diet.5. Evaluation of the STR/Ort mice as the novel obesity model mice : As a result of having evaluated the STR/Ort mice which develop natural murine osteoarthritis, it was easy to develop the abdominal fat obesity in the normal diet, and the sensitivity for the high fat diet was better than the C57BL/6J mice.6. Evaluation of the functional food ingredients in C57BL/6J and KK/Ta mice : I evaluated the functional food ingredients in C57BL/6J and KK/Ta mice It was thought that adequate model should be chosen depending on a purpose of the research so that a KK/Ta mouse was different from a C57BL/6J mouse in the response to the diet. Less

1. C57 BL/6 J小鼠（野生型; +/+）中的饮食诱导反应：本人检查了野生型（+1+）小鼠中的饮食诱导反应，目的是收集ob异型小鼠（ob/+）的背景数据。结果表明，在野生型小鼠（+1+）中，高脂饮食增加了腹部脂肪堆积，但认为脂肪组织的功能没有受到显著影响. ob异种瘦素基因敲除小鼠（ob/+）和野生型小鼠（+/+）之间的饮食诱导反应的比较：作为ob/+和+/+雄性小鼠之间的饮食诱导反应的比较结果，两种小鼠模型均敏感地观察到饮食诱导反应。这些结果表明，在该模型中，高脂饮食的影响大于基因型.在异种（ob/+）和野生型（+/+）小鼠中评价功能性食品成分：结果，在大豆和野生型（+/+）小鼠中均观察到腹部脂肪细胞增大的抑制作用。 ...更多信息磷脂和蛋黄磷脂的评价。瘦素受体基因敲除小鼠（db/+）和野生型小鼠（+/+）之间的饮食诱导反应的比较：我用交配方法将db/+小鼠与C57 BL/6 J小鼠的背景杂交，并比较饮食诱导反应。结果，db/+和+/+小鼠之间的差异是显著的，并且与正常饮食相比，在高脂肪饮食中观察到显著差异。STR/Ort小鼠作为新型肥胖模型小鼠的评价：对自然发生小鼠骨关节炎的STR/Ort小鼠进行评价的结果表明，在正常饮食条件下容易发生腹脂性肥胖，对高脂饮食的敏感性优于C57 BL/6 J小鼠.在C57 BL/6 J和KK/Ta小鼠中评价功能性食品成分：我在C57 BL/6 J和KK/Ta小鼠中评价了功能性食品成分。认为应根据研究目的选择适当的模型，使得KK/Ta小鼠在对饮食的反应上不同于C57 BL/6 J小鼠。少