Study on Magnetic Targeting of Magnetized Medicine Droplet
Study on Magnetic Targeting of Magnetized Medicine Droplet
批准号:
17560160
负责人:
YAMANE Ryuichiro
金额:
$2.39万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2007
中文摘要
磁流体的医学应用之一是通过磁力将磁性药物靶向病变部位。抗癌药物不仅攻击癌细胞,而且攻击正常细胞,并且希望药物仅集中于患病部分。其中一种方法是将药物磁化或制成药物的磁性乳液,并利用磁力将其固定在患病部位。为此目的,磁性液滴或磁性乳液应当被捕获到血管的壁表面上并保持在与血液流动相反的位置。本研究以药物和血液为研究对象,分别用磁流体和水代替,进行了三种类型的实验。1.磁液滴的磁捕获:对落入水中的磁流体液滴进行了磁捕获实验。磁性液滴的捕获根据磁力的强度分为四种类型。研究了捕获条件.磁性液滴的磁性支撑:将磁性流体的液滴放置在通道的底部上,并利用磁力逆着水流保持在适当位置。针状的尖峰出现在液滴上,并随着流动向下游移动。观察并分析了棘突的运动情况.表面张力对液滴形状的影响:用不同材料覆盖液滴表面,观察液滴表面尖峰的形状。
英文摘要
One of the medical applications of the magnetic fluid is to target the magnetic drug to the diseased part by means of the magnetic force. The anticancer drug attacks not only the cancer cells but also the normal ones, and it is desirable to concentrate the drug only to the diseased part. One of the methods is to magnetize the drug or to make the magnetic emulsion of the drug and to fix it to the diseased part using the magnetic force. For this purpose the magnetic droplet or the magnetic emulsion should be captured to the wall surface of the vessel and held in position against the flow of the blood. In the present research, as the basis of this problem the drug and the blood were replaced with the magnetic fluid and the water, respectively, and three types of experiments were conducted.1.Magnetic capture of magnetic droplet : Trial was conducted to capture the magnetic fluid droplet falling in the water. Capture of the magnetic droplet is classified into four types according to the strength of the magnetic force. The condition of capture is examined.2. Magnetic support of magnetic droplet : A droplet of the magnetic fluid was placed on the floor of the channel and was held in position against the flow of the water with the magnetic force. The needle-like spikes emerged on the droplet and moved downstream with the flow. The motion of the spikes was observed and analyzed.3. Effect of surface tension on shape of droplet : Surface of the droplet was covered with different materials and the shape of the spikes was observed.
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Fundamental Research on Magnetic Drug Targeting(in Japanese)
磁性药物靶向的基础研究(日语)
DOI:
--
发表时间:
2008
期刊:
Report of Kokushikan University High-Tech Research Center (in press)
影响因子:
--
作者:
[R., Yamane]
通讯作者:
Yamane
Experimental Research oll Tribological Properties of Mn_0.78Zn_0.22Fe_2O_4Magnetic Fluid
Mn_0.78Zn_0.22Fe_2O_4磁流体摩擦学性能的实验研究
DOI:
--
发表时间:
2007
期刊:
磁性流体連合講演論文集講演会講演論文集
影响因子:
--
作者:
[L. J. Wang, C. W. Guo, R. Yamane]
通讯作者:
R. Yamane
薬剤磁気ターゲッティングの基礎的研究
药物磁靶向基础研究
DOI:
--
发表时间:
2006
期刊:
国士舘大学ハイテクリサーチセンタ平成17年度研究報告書 (印刷中)
影响因子:
--
作者:
[山根隆一郎, 崎山伸彦]
通讯作者:
崎山伸彦
Fundamental Research on Magnetic Support of Three-Dimensional Magnetic Drug Droplet(in Japanese)
三维磁性药滴磁支撑的基础研究(日文)
DOI:
--
发表时间:
2007
期刊:
Report of Kokushikan University High-Tech Research Center
影响因子:
--
作者:
[R., Yamane]
通讯作者:
Yamane
Magnetic Capture of Falling Magnetic Fluid Droplet(in Japanese)
磁力捕获下落的磁流体液滴(日语)
DOI:
--
发表时间:
2007
期刊:
Proc. Symp. on Magnetic Fluid
影响因子:
--
作者:
[R., Yamane, T., Ebihara]
通讯作者:
Ebihara
共 19 条
Study on Formation and Stability of Virtual Channel Levitated by Strong Magnetic Field
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批准号:14550159
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2002
-
负责人:YAMANE Ryuichiro
-
依托单位:
Levitation and Non-Contacting Control of Liquid Flow Utilizing Mose's Effect
-
批准号:10450072
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$5.63万
-
财政年份:1998
-
负责人:YAMANE Ryuichiro
-
依托单位:
Development of the bouble difusion augmentator of interface instability type by using an unsteady Lorentz force
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批准号:05555057
-
项目类别:Grant-in-Aid for Developmental Scientific Research (B)
-
资助金额:$5.12万
-
财政年份:1993
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负责人:YAMANE Ryuichiro
-
依托单位:
Development of molten metal holder of Faraday type
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批准号:02555038
-
项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$2.69万
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财政年份:1990
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负责人:YAMANE Ryuichiro
-
依托单位:
Trial Manufacture of Sheet Former for Molten metals by means of Electromagnetic Force
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批准号:63850039
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项目类别:Grant-in-Aid for Developmental Scientific Research
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资助金额:$1.98万
-
财政年份:1988
-
负责人:YAMANE Ryuichiro
-
依托单位:
海外基金