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Study on Magnetic Targeting of Magnetized Medicine Droplet

磁化药滴磁靶向研究

基本信息

批准号：
17560160
负责人：
YAMANE Ryuichiro
金额：
$ 2.39万
依托单位：
Kokushikan University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17560160/
关键词：
Magnetic fluid Functional fluid Magnetic targeting Drug delivery Magnetic capture Magnetic support Magnetic droplet Spike 薬剤中界面不安定

项目摘要

One of the medical applications of the magnetic fluid is to target the magnetic drug to the diseased part by means of the magnetic force. The anticancer drug attacks not only the cancer cells but also the normal ones, and it is desirable to concentrate the drug only to the diseased part. One of the methods is to magnetize the drug or to make the magnetic emulsion of the drug and to fix it to the diseased part using the magnetic force. For this purpose the magnetic droplet or the magnetic emulsion should be captured to the wall surface of the vessel and held in position against the flow of the blood. In the present research, as the basis of this problem the drug and the blood were replaced with the magnetic fluid and the water, respectively, and three types of experiments were conducted.1.Magnetic capture of magnetic droplet : Trial was conducted to capture the magnetic fluid droplet falling in the water. Capture of the magnetic droplet is classified into four types according to the strength of the magnetic force. The condition of capture is examined.2. Magnetic support of magnetic droplet : A droplet of the magnetic fluid was placed on the floor of the channel and was held in position against the flow of the water with the magnetic force. The needle-like spikes emerged on the droplet and moved downstream with the flow. The motion of the spikes was observed and analyzed.3. Effect of surface tension on shape of droplet : Surface of the droplet was covered with different materials and the shape of the spikes was observed.

磁流体的医学应用之一是通过磁力将磁性药物靶向病变部位。抗癌药物不仅攻击癌细胞，而且攻击正常细胞，并且希望药物仅集中于患病部分。方法之一是将药物磁化或制成药物的磁性乳剂，并利用磁力将其固定在患病部位。为此目的，磁性液滴或磁性乳液应当被捕获到血管的壁表面上并保持在与血液流动相反的位置。本研究以药物和血液为基础，分别用磁性流体和水代替，进行了三种类型的实验。1.磁性液滴的磁性捕获：尝试捕获落入水中的磁性流体液滴。磁性液滴的捕获根据磁力的强度分为四种类型。研究了捕获条件.磁性液滴的磁性支撑：将磁性流体的液滴放置在通道的底部上，并利用磁力逆着水流保持在适当位置。针状的尖峰出现在液滴上，并随着流动向下游移动。观察并分析了棘突的运动情况.表面张力对液滴形状的影响：用不同材料覆盖液滴表面，观察液滴表面尖峰的形状。