Study on the evaluation of sensitizing potency in industrial chemicals and the application to risk assessment

工业化学品致敏效力评价及其在风险评估中的应用研究

• 批准号: 17590520
• 负责人: AOYAMA Kohji
• 金额: $ 2.37万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17590520/
• 关键词: Allergy; Mice; Respiratory sensitivity; Risk assessment; prediction test; 呼吸器感作; マウスモデル; 感作性予知試験法

We advanced the development of prediction test for the respiratory sensitivity of low molecular chemicals used in industrial places. Consequently, this prediction test provided the evaluation of sensitizing potency as well as the determination of sensitization. Sensitizing potency was obtained from the concentration of induction by which a certain intensity of histopathological lesion was induced. We also examined the application of sensitizing potency to the risk assessment in industrial health, and found a possible modeling for decide the concentration for work management in industrial sensitizers. Reproducibility and the validity of this prediction test were confirmed by conducting it in the other research institution.

提出了工业场所使用的低分子化学品呼吸敏感性预测试验的发展。因此，该预测试验提供了致敏效力的评价以及致敏性的测定。从诱导一定强度的组织病理学损伤的诱导浓度获得致敏效力。本文还探讨了致敏效价在工业卫生风险评价中的应用，为工业致敏物的工作管理提供了一种可能的浓度确定模型。通过在其他研究机构进行预测试验，证实了该预测试验的重现性和有效性。