Establishment of the Measurement lhchnique for Cerebral Blood Flow and Metabolism during Brain Activation using MRI and Nearinfrared Spectroscopy.
建立使用 MRI 和近红外光谱测量脑激活期间脑血流量和代谢的技术。
基本信息
- 批准号:17591307
- 负责人:
- 金额:$ 2.04万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2005
- 资助国家:日本
- 起止时间:2005 至 2007
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We have developed a simultaneous measurement system using functional magnetic resonance imaging (fMRI) and near-infrared spectroscopy (NIRS) technique. Twenty-two normal volunteers aged 21 to 43 were studied with a 3T MRI system (GEYMS Signa Horizon LX) and an optical imaging system (Hitachi ETG-100). Optical cable-bundle was extended to the MR head-coil to set up the simultaneous acquisition system. Various photic patterns and durations were used for the visual activations. The temporal characteristics of blood oxygenation level-dependent (BOLD) responses to brief visual stimulation of the human primary visual cortex (V1) were investigated using an event-related functional magnetic resonance imaging (ER-fMRI) technique. The magnitude and extent of the BOLD response were examined by changing the stimulus duration of a reversing checkerboard between 1 to 6 secs. In addition, the relationship between measured and predicted BOLD responses was evaluated. Results show that the peak height and the area above the baseline increased linearly as a function of stimulus duration. Retinotopic and event-related studies showed that the localization and linearity of the responses with these two systems were nearly identical. The fMRI contrast (BOLD) uses deoxyhemoglobin information, and NIRS uses both oxyhemoglobin and deoxyhemoglobin dynamics (the sum of these are named total hemoglobin, related to cerebral blood volume). Simultaneous measurement system provides and integrates the spatial and temporal dynamics with respect to the brain physiological parameters (e.g., CBF, CBV, and CMRO2).
我们开发了一种使用功能磁共振成像(FMRI)和近红外光谱(NIRS)技术的同步测量系统。采用3T磁共振成像系统(GEYMS Signa Horizon LX)和光学成像系统(Hitachi ETG-100)对22名21~43岁的正常志愿者进行了研究。将光缆束延伸到磁共振头线圈,建立了同步采集系统。视觉激活使用了不同的光图案和持续时间。采用事件相关功能磁共振成像(ER-fMRI)技术,研究了人类初级视皮层(V1)对短暂视觉刺激的血氧水平依赖性(BOLD)反应的时间特征。通过改变反转棋盘的刺激持续时间在1到6秒之间来检查大胆反应的幅度和程度。此外,还评估了测量和预测的大胆反应之间的关系。结果表明,峰值高度和高于基线的面积随着刺激时间的延长而线性增加。视网膜原位研究和事件相关研究表明,这两个系统的反应的局部性和线性几乎相同。FMRI对比度(BOLD)使用脱氧血红蛋白信息,而NIRS使用氧合血红蛋白和脱氧血红蛋白动力学(两者之和称为总血红蛋白,与脑血容量相关)。同时测量系统提供并集成了与脑生理参数(如CBF、CBV和CMRO2)相关的空间和时间动力学。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Measurements of BOLD and total-Hb by fMRI and Near-lnfrared Snectroscouv(NIBS)during Graded Visual Stimulation
在分级视觉刺激期间通过 fMRI 和近红外 Snectroscouv (NIBS) 测量 BOLD 和总 Hb
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:Takayuki;Obata;Moyoko;Tomiyasu;Kenichi;Kashikura;Yoshiyuki;Hirano;Hiroi;Nonaka;Masaya;Hirano;Hiroo;Ikehira;K Kashikura
- 通讯作者:K Kashikura
Measurements of BOLD and total-Hb by fMRI and Near-Infrared Spectroscopy(NIRS)during Graded Visual Stimulation
在分级视觉刺激期间通过 fMRI 和近红外光谱 (NIRS) 测量 BOLD 和总 Hb
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:Takayuki;Obata;Moyoko;Tomiyasu;Kenichi;Kashikura;Yoshiyuki;Hirano;Hiroi;Nonaka;Masaya;Hirano;Hiroo;Ikehira;K Kashikura;K. Kashikura
- 通讯作者:K. Kashikura
Abnormal pontine activation in pathological laughing as shown by functional magnetic resonance imaging
- DOI:10.1136/jnnp.2005.073288
- 发表时间:2006-12-01
- 期刊:
- 影响因子:11
- 作者:Kosaka, H.;Omata, N.;Wada, Y.
- 通讯作者:Wada, Y.
An Alternative Interpretation for Stimulus-Related Signal Changes in Diffusion-Weighted fMRI
扩散加权功能磁共振成像中刺激相关信号变化的另一种解释
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:J. Kershaw;M. Tomiyasu;K. Kashikura;Y. Hirano;H. Nonaka;M. Hirano;H. Ikehira;I. Kanno;T. Obata
- 通讯作者:T. Obata
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