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A study on regional difference of reaction to trigeminal stimulation

三叉神经刺激反应的区域差异研究

基本信息

批准号：
17592058
负责人：
KAMEKURA Nobuhito
金额：
$ 2.23万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17592058/
关键词：
trigeminal nerve regional blood flow pulsed doppler flow meter circulatory depression sympathetic nerve パルスドップラ血流計電磁血流計

项目摘要

Nociceptive stimulation to trigeminal nerve of rabbit causes fluctuations in blood pressure. We examined what stimulation raised or lowered blood pressure and observed change of autonomic nervous activity during stimulation. Stimulation of infraorbital nerve with 5 Hz caused depressor response, stimulation with 25 Hz caused pressor response. When blood pressure fell, a decrease in renal sympathetic nerve activity (RSNA) was observed. On the other hand, when blood pressure fell, a decrease in renal sympathetic nerve activity (RSNA) was observed. On the other hand, when blood pressure rose, an increase in RSNA was observed. These results suggested that the circulatory response elicited by trigeminal stimulation was a somato-sympathetic nerve reflex whose efferent pathway was sympathetic nerve. Next, we examined the factors that influenced these responses. Arterial baroreflex enhanced the depressor response and inhibited the pressor response and inhibited the pressor response. Propofol in … More hibited the pressor response and fentanyl inhibited the depressor response. Isoflurane and phentolamine inhibited the pressor and depressor responses. These results suggested there were different pathways in medulla causing the depressor and pressor responses elicited by trigeminal stimulation. In addition, we examined the change in blood flow volume of arteria carotis communis (CA), arteria renalis (RA), and arteria femoralis (FA) when the depressor response occurred, and the influence of fentanyl on the blood flow volume of each artery was observed. We observed the change in the blood flow volume when trigeminal nerve was stimulated and mean arterial pressure was lowered. The change was large in order of RA, FA, and CA, and there was no significant difference in the change of CA and FA. These results suggested that there were regional differences in level of a decrease in sympathetic nerve activity and self-adjustment ability of the blood flow. Though a decrease in blood pressure by trigeminal stimulation became small by administering fentanyl, the regional differences of arterial flow volume did not be affected with fentanyl. Less

对兔三叉神经的伤害性刺激引起血压波动。我们检查了什么刺激会升高或降低血压，并观察了刺激过程中自主神经活动的变化。5 Hz刺激眶下神经引起降压反应，25 Hz刺激眶下神经引起升压反应。当血压下降时，观察到肾交感神经活动（RSNA）减少。另一方面，当血压下降时，观察到肾交感神经活动（RSNA）减少。另一方面，当血压升高时，观察到RSNA的增加。这些结果表明，三叉神经刺激引起的循环反应是一种躯体-交感神经反射，其传出通路为交感神经。接下来，我们研究了影响这些反应的因素。动脉压力反射增强了降压反应，抑制了升压反应，抑制了升压反应。异丙酚抑制了升压反应，芬太尼抑制了降压反应。异氟醚和酚妥拉明抑制升压和降压反应。这些结果表明，三叉神经刺激引起的降压和升压反应在髓质中有不同的通路。此外，我们还检测了降压反应发生时颈共动脉（CA）、肾动脉（RA）和股动脉（FA）血流量的变化，并观察芬太尼对各动脉血流量的影响。我们观察了刺激三叉神经和降低平均动脉压时血流量的变化。RA、FA、CA的变化顺序较大，CA、FA的变化无显著性差异。这些结果表明，交感神经活动减弱程度和血流自我调节能力存在区域差异。虽然芬太尼对三叉神经刺激血压下降的影响不大，但芬太尼对动脉血流容量的区域差异没有影响。少