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Trace element analysis, focused on d-transition elements, of oral mucosa of patents with oral lichen planus by PIXE method

采用PIXE法对口腔扁平苔藓患者口腔粘膜进行微量元素分析，重点是d-过渡元素

基本信息

批准号：
17592102
负责人：
SUGIYAMA Yoshiki
金额：
$ 1.9万
依托单位：
Iwate Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17592102/
关键词：
accelerator dental science clinical analytical chemistry human environment oral lichen planus metallic element

项目摘要

1. We made a comparative study of the elements in oral mucosae of 29 patients with oral lichen planus (OLP group) and of 100 healthy persons (control group) by Particle Induced X-Ray Emission (PIXE) method.2. We detected 17 trace elements and 11 contaminated elements in the oral mucosae of both groups.3. We found by the PIXE method that the mean values of Zn and Pd, which are d-transitional elements and considered to cause allergic reaction, were significantly higher values in the oral mucosae of the OLP patients than in those of the healthy persons.4. Elements in normal oral mucosa, saliva and serum were determined by Particle Induced X-ray Emission (PIXE) method. The samples were taken from 4 healthy persons (3 male and 1 female) ages 26 to 77 years with a mean age of 49.0 years old. Twenty-seven elements were detected in normal oral mucosa. Thirty-one elements were detected in saliva. Thirty elements were detected in serum. Twelve elements (Na, Mg, P S, Cl K, Ca, Fe, Cu, Zn, Br, Al) were in all samples. In the mean value of Na, Mg, P S, Cl K, Ca, Mn, Fe, Co, Cu, Zn, Se, Al, Ti and Pb, oral mucosa showed higher value than the saliva and serum. In the mean value of Rb, oral mucosa showed higher value than the saliva. Ten contaminated elements were detected and especially Al were in all samples.

1.采用粒子激发X射线荧光分析（PIXE）方法对29例口腔扁平苔藓患者（OLP组）和100例健康人（对照组）口腔粘膜中的元素进行了比较研究.在两组口腔粘膜中检测到17种微量元素和11种污染元素. PIXE分析发现OLP患者口腔粘膜中引起过敏反应的d-过渡元素Zn和Pd的平均值明显高于健康人.本文用粒子激发X射线荧光分析法（PIXE）测定了正常口腔粘膜、唾液和血清中的元素。样本取自4名健康人（3男1女），年龄26 - 77岁，平均年龄49.0岁。在正常口腔粘膜中检测到27种元素。唾液中检测到31种元素。在血清中检测到30种元素。所有样品中含有Na、Mg、P、S、Cl、K、Ca、Fe、Cu、Zn、Br、Al等12种元素。口腔粘膜Na、Mg、P、S、Cl、K、Ca、Mn、Fe、Co、Cu、Zn、Se、Al、Ti、Pb的平均值均高于唾液和血清。在Rb平均值中，口腔粘膜的含量高于唾液。共检测出10种污染元素，其中Al含量最高。