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Trace element analysis, focused on contaminated elements, of oral mucosa of patents with oral lichen planus by PIXE method

采用PIXE法对口腔扁平苔藓患者口腔粘膜进行微量元素分析，重点关注污染元素

基本信息

批准号：
14571908
负责人：
SUGIYAMA Yoshiki
金额：
$ 1.6万
依托单位：
Iwate Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571908/
关键词：
Lichen planus Oral mucosa Trace element Particle Induced X-Ray Emission method

项目摘要

1.We made a Comparative study of the trace elements in oral mucosae of 22 patients with oral lichen planus (OLPgroup) and of 100 healthy persons (control group) by Particle Induced X-Ray Emission (PIXE) method.2.We detected 17 trace elements and 11 contaminated elements in the oral mucosae of both groups.3.The mean values of Se and Rb were significantly lower in the OLP group than in the control group. As for the females over 30 years old, the OLP group showed significantly higher values of Zn and Sr than the control group. The mean values of the other essential and contaminated elements did not differ significantly between the groups, although there was a trend toward higher values in the OLP group.4.We found by the PIXE method that Zn, Fe and Pd, which are d-transitional elements and considered to cause allergic reaction, showed higher values in the oral mucosae of the OLP patients than in those of the healthy persons.5. As to the trace elements in the normal mucosae, Si, Cr, Mn, Fe, Ni, Cu, Zn and Se were detected in greater than 800o of the samples. As to the ultratrace elements, Br and Rb were detected in greater than 90% of the samples.6.Al and Pb were detected in all the samples of normal oral mucosae. In the mean value of Al, the females under 39 years old showed a higher value than the females over 40 years old. In the mean value of Pb, the males over 40 years old showed a higher value than the females over 40 years old. The concentration of Al had a tendency to decrease with aging, while that of Pb had a tendency to increase. The concentration values of Al and Pb showed no significant differences between the two subgroups of normal mucosae with and without metallic prosthetic restorations.

1.对22例口腔扁平苔藓患者口腔粘膜中微量元素进行了比较研究（OLP组）和100名健康人（对照组）通过粒子诱导X射线发射（PIXE）方法：2.检测两组口腔粘膜中17种微量元素和11种污染元素。对照组对于30岁以上的女性，OLP组的Zn和Sr值显著高于对照组。其他必需元素和污染元素的平均值在各组间差异不显著，但在OLP组中有增高的趋势。4. PIXE分析发现，被认为引起过敏反应的d-过渡元素Zn、Fe和Pd在OLP患者口腔粘膜中的含量高于健康人。正常粘膜中微量元素中，Si、Cr、Mn、Fe、Ni、Cu、Zn、Se在800 o以上的样品中检出。在超微量元素中，Br和Rb的检出率均在90%以上。6. Al和Pb在所有正常口腔粘膜中均有检出。在Al的平均值中，39岁以下女性高于40岁以上女性。在铅的平均值中，40岁以上的男性高于40岁以上的女性。Al的浓度有降低的趋势，而Pb的浓度有增加的趋势。铝和铅的浓度值显示两个亚组之间的正常粘膜与金属修复体之间没有显着差异。