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Mechanism of the beneficial effects of exercise training and lipid lowering drug therapy

运动训练与降脂药物治疗的有益作用机制

基本信息

批准号：
18500395
负责人：
ITO Osamu
金额：
$ 2.44万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18500395/
关键词：
exercise training HMG-CoA reductase inhibitor glucose and lipid metabolism hepatic steatosis antihypertensive effect pleiotropic effect kidney nitric oxide 高血圧自然発症ラット降圧作用一酸化窒素 Zucker肥満ラットアディポサイトカイン

项目摘要

Effects of a combination therapy of the exercise training (Ex) and HMG-CoA reductase inhibitor, statin were determined. Male Zucker-fatty-rats were divided into four groups; a control, an atorvastatin (ATV), an Ex and a combination therapy (ATV+Ex) groups. After 10 weeks, the plasma glucose was not different in the ATV or the. Ex group, but it was lower in the ATV+Ex group than in the control group. The plasma total cholesterol was lower in the Ex and the ATV+Ex groups. The plasma triglyceride was lower in all three experimental groups. The plasma insulin, leptin and adiponectin were not significantly different among the four groups.-The hepatic triglyceride was lower in the Ex and the ATV+Ex groups, and the minimum levels were observed in the Ex group. The combination therapy has beneficial effects on reduction of the plasma. glucose and lipids and improvement of hepatic steatosis without the change of the plasma adipocytokines in Zucker fatty rats.Effects of ATV and Ex on: blood pressure and the expression of endothelial and neuronal NO synthase (eNOS, nNOS) in spontaneously hypertensive rats (SHR) were determined. Male <SHR were divided randomly into four groups; a control group, an ATV group, an Ex group, and a ATV+ Ex group. After 8 weeks, systolic blood pressure (SBP) was significantly lower in the ATV, Ex and ATV +Ex groups, compared with the control group. ATV induced eNOS protein in the renal cortex, medulla and thoracic. aorta, and nNOS protein in the renal medulla and thoracic aorta. Ex-induced eNOS protein specifically in the renal medulla, and nNOS protein in the renal cortex, medulla and thoracic aorta. ATV and Ex prevents the development of hypertension in SHR in part through the induction of NOS proteins, which is regulated by Ex and ATV in a different manner.

观察运动训练(Ex)与HMG-CoA还原酶抑制剂他汀类药物联合治疗的效果。雄性Zucker肥胖大鼠分为对照组、阿托伐他汀(ATV)组、阿托伐他汀(Ex)组和联合用药组(ATV+Ex)。10周后，ATV组和对照组的血糖无明显差异。EX组，但ATV+Ex组低于对照组。血浆总胆固醇在Ex组和ATV+Ex组较低。三个实验组的血浆甘油三酯均较低。血浆胰岛素、瘦素和脂联素在四组间无显著差异。-肝脏甘油三酯在Ex和ATV+Ex组中较低，且在Ex组中最低。联合治疗对降低血浆浓度有一定的作用。观察ATV和Ex对自发性高血压大鼠(SHR)血压、血管内皮细胞和神经元型一氧化氮合酶(eNOS、nNOS)表达的影响。将雄性SHR随机分为4组：对照组、ATV组、Ex组和ATV+Ex组。8周后，ATV组、Ex组和ATV+Ex组的收缩压(SBP)均显著低于对照组。ATV诱导大鼠肾皮质、髓质和胸腺eNOS蛋白表达。肾髓质和胸主动脉有nNOS蛋白表达。EX诱导的eNOS蛋白定位于肾髓质，nNOS蛋白定位于肾皮质、髓质和胸主动脉。ATV和Ex在一定程度上通过诱导一氧化氮合酶蛋白来防止SHR高血压的发展，而NOS蛋白是由Ex和ATV以不同的方式调节的。