Mechanism of beneficial effects of combination therapy with exercise training and antioxidant

运动训练和抗氧化联合疗法的有益作用机制

• 批准号: 20500437
• 负责人: ITO Osamu
• 金额: $ 2.91万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500437/
• 关键词: リハビリテーション医学; リハビリテーション; 酸化ストレス; 循環器・高血圧; 脂質; 動物

H_2O_2, among reactive oxygen species, upregulates the nitric oxide (NO) production and NO synthase (NOS) expression and controls glomerular filtration rate (GFR) in the kidney of spontaneously hypertensive rats (SHR). Exercise training (EX) upregulates the NO production and NOS expression in the kidney of SHR, and H_2O_2mediates these effects of EX. Superoxide dismutase mimetic, tempol enhances these effects of EX in SHR, such as antihypertension, increase of GFR and upregulation of the NO production and NOS expression in the kidney.

H_2O_2可上调自发性高血压大鼠(SHR)肾脏一氧化氮(NO)的生成和一氧化氮合酶(NOS)的表达，并控制肾小球滤过率(GFR)。运动训练(EX)可上调SHR肾脏NO的生成和NOS的表达，而H_2O_2可介导运动训练的这种作用。Tempol类似超氧化物歧化酶，可增强EX对SHR的降压作用，增加肾小球滤过率，上调肾脏NO生成量和NOS表达。

项目成果

Effect of apocynin and tempol on the production of nitric oxide and the expression of nitric oxide synthase in the kidney of spontaneously hypertensive rats.

罗布麻宁和tempol对自发性高血压大鼠肾脏一氧化氮生成及一氧化氮合酶表达的影响

• 发表时间: 2009
• 作者: 曹鵬宇;伊藤修;郭〓;伊藤大亮;室谷嘉一;高島健太;森信芳;伊藤貞嘉;上月正博
• 通讯作者: 上月正博

高血圧自然発症ラットの腎NO合成酵素発現へのtempolとapocyninの長期投与の効果

长期服用tempol和罗布麻宁对自发性高血压大鼠肾NO合酶表达的影响

• 发表时间: 2008
• 作者: 曹鵬宇;伊藤修;伊藤大亮;室谷嘉一;金澤雅之;上月正博
• 通讯作者: 上月正博

Effect of exercise training and superoxide dismutase mimetic tempol on blood pressure and the expression of nitric oxide synthase in spontaneously hypertensive rats.

运动训练和超氧化物歧化酶模拟Tempol对自发性高血压大鼠血压及一氧化氮合酶表达的影响

• 发表时间: 2008
• 作者: Cao P;Ito O;Ito D;Muroya Y;Takashima K;Chang Y;Kanazawa M;Kohzuki M.
• 通讯作者: Kohzuki M.

Effect of exercise training on renal oxidative stress and renal NO production system in SHR

运动训练对SHR肾氧化应激及肾NO生成系统的影响

• 发表时间: 2010
• 作者: Cao P;Ito O;Ito D;Muroya Y;Guo Q;Ron R;Mori T;Ito S;Kohzuki M
• 通讯作者: Kohzuki M

Effect of apocynin and tempol on the expression of nitric oxide synthase and oxidative stress in the kidney of spontaneously hypertensive rats.

罗布麻宁和tempol对自发性高血压大鼠肾脏一氧化氮合酶表达及氧化应激的影响

• 发表时间: 2010
• 作者: 曹鵬宇;伊藤修;郭〓;伊藤大亮;室谷嘉一;森信芳;伊藤貞嘉;上月正博
• 通讯作者: 上月正博