Mechanism of beneficial effects of combination therapy with exercise training and antioxidant
Mechanism of beneficial effects of combination therapy with exercise training and antioxidant
批准号:
20500437
负责人:
ITO Osamu
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
H_2O_2, among reactive oxygen species, upregulates the nitric oxide (NO) production and NO synthase (NOS) expression and controls glomerular filtration rate (GFR) in the kidney of spontaneously hypertensive rats (SHR). Exercise training (EX) upregulates the NO production and NOS expression in the kidney of SHR, and H_2O_2mediates these effects of EX. Superoxide dismutase mimetic, tempol enhances these effects of EX in SHR, such as antihypertension, increase of GFR and upregulation of the NO production and NOS expression in the kidney.
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Effect of exercise training on renal oxidative stress and renal NO production system in SHR
运动训练对SHR肾氧化应激及肾NO生成系统的影响
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Cao P, Ito O, Ito D, Muroya Y, Guo Q, Ron R, Mori T, Ito S, Kohzuki M]
通讯作者:
Kohzuki M
Effect of apocynin and tempol on the production of nitric oxide and the expression of nitric oxide synthase in the kidney of spontaneously hypertensive rats.
罗布麻宁和tempol对自发性高血压大鼠肾脏一氧化氮生成及一氧化氮合酶表达的影响
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[曹鵬宇, 伊藤修, 郭〓, 伊藤大亮, 室谷嘉一, 高島健太, 森信芳, 伊藤貞嘉, 上月正博]
通讯作者:
上月正博
高血圧自然発症ラットの腎NO合成酵素発現へのtempolとapocyninの長期投与の効果
长期服用tempol和罗布麻宁对自发性高血压大鼠肾NO合酶表达的影响
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[曹鵬宇, 伊藤修, 伊藤大亮, 室谷嘉一, 金澤雅之, 上月正博]
通讯作者:
上月正博
Effect of exercise training and superoxide dismutase mimetic tempol on blood pressure and the expression of nitric oxide synthase in spontaneously hypertensive rats.
运动训练和超氧化物歧化酶模拟Tempol对自发性高血压大鼠血压及一氧化氮合酶表达的影响
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Cao P, Ito O, Ito D, Muroya Y, Takashima K, Chang Y, Kanazawa M, Kohzuki M.]
通讯作者:
Kohzuki M.
Effect of apocynin and tempol on the expression of nitric oxide synthase and oxidative stress in the kidney of spontaneously hypertensive rats.
罗布麻宁和tempol对自发性高血压大鼠肾脏一氧化氮合酶表达及氧化应激的影响
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[曹鵬宇, 伊藤修, 郭〓, 伊藤大亮, 室谷嘉一, 森信芳, 伊藤貞嘉, 上月正博]
通讯作者:
上月正博
共 41 条
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