Effects of Lifestyle Factors on Clinical Outcomes of Prevention and Care of Diabetes

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Diabetes mellitus and other lifestyle-related diseases are one of main health issues in most industrialized countries including Japan. Necessity and importance of their clinical evidences, which is useful in establishing strategies and for their prevention and care, are more and more increasing in these days. In this project, we evaluated effects of lifestyle factors such as diet, exercise, smoking, alcohol intake, etc. on various clinical parameters related to prevention and care of diabetes and other lifestyle-related diseases. By utilizing historical cohort design, meta-analysis and other methods, we could establish many important clinical evidences that could be applied in clinical settings. For example, we could find that smoking is a very important and dose-dependent risk factor for Japanese patients with diabetes to develop diabetic nephropathy. We could also clarify appropriate and suitable way of exercise for efficiently increasing HDL-cholesterol. Such results were reported in many international journals like Diabetes Care, Annals of Internal Medicine, and so on.