Development of novel-functionalized compounds using silver-vorous molecules

我们已经合成了(A)具有四个芳香环的手性臂环化合物，(B)具有两种芳香环的C2v对称臂环化合物，以及(C)在侧臂上具有附加结合位点的臂环化合物。项目A：制备了两种手性旋环，(i)在旋环上有一个手性位点，（ii）在侧臂上有一个手性位点。CD谱显示，当配体与Ag^+形成配合物时，手性急剧增加。项目B：制备了具有C2v对称臂环的新配体，该配体具有两种芳香（忘了A环），3,5 -二氟双酶和二氟苯和4-(4-pyrydyl)苄基。冷态ESIMS、1H NMR滴定实验和x射线结构表明配体形成3:5（配体：Ag^+）配合物。复合物的形状看起来像纳米三叶草。项目C：制备了芳香侧臂上有乙烯基单元的新配体。冷态ESIMS表明，当配体形成Ag^+配合物时，配体对碱金属阳离子的络合能力增强。

We have synthesized (A) chiral armed-cyclens having four aromatic rings, (B) C2v symmetrical armed-cyclens having two kinds of aromatic rings, and (C) armed-cyclens having an additional binding site in the side-arms.Project A:Two kinds chiral armed-cyclens, (i) which have a chiral site at cyclen ring and (ii) which have a chiral sited at a side-arm, have been prepared. Drastic increase of chirality was observed by CD spectra, when the ligands form complexes with Ag^+.Project B :New ligands having C2v symmetrical armed-cyclens having two kinds of aromatic (FORGOT A rings, 3, 5-difluorobenzylanddifluorobenzyl and 4-(4-pyrydyl)benzyl group were prepared. From the cold ESIMS, 1H NMR titration experiments and X-ray structures suggested that the ligand form 3 : 5 (ligand : Ag^+) complex. The shape of the complex is looks like nano-trefoil.Project C:New ligands having ethyleneoxy units at the aromatic side-arms have been prepared. Cold ESIMS suggested that the complexing abilities of ligands toward alkali metal cations increased when the ligand form Ag^+ complex.