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A analysis of bone quality of growing rat mandible by a novel evaluation system

新型评价体系对生长大鼠下颌骨骨质量的分析

基本信息

批准号：
18560677
负责人：
FUJITANI Wataru
金额：
$ 2.51万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18560677/
关键词：
bone quality rat mandible biological apatite(BAp)preferred alignment of BAP X-ray diffraction in vivo stress distribution

项目摘要

We focused on the effect of growing and biting stress on the quality and quantity of rat and beagle mandible. The effect of the biting stress was analyzed just under the tooth root of biting and non-biting animal. The non-biting animal was achieved by tooth extraction. The preferred alignment of the c-axis in biological apatite (BAp) as a bone quality parameter was analyzed by means of the novel technique based on the X-ray diffraction.The volume and the density as conventional parameters for bone tissue were also evaluated. Following results were obtained from this research.(1) The cross-sectional area of cortical bone monotonically increased with growing in both in rat and in beagle. However,the increase in bone density and the apatite alignment saturated earlier than that in cortical area.The distribution of the bone density and Bap alignment showed significantly varied depending on the position.(2) In general in the mandible, the uni-directional BAp alignment along the mesiodistal axis could be found. However, just under the tooth root, Bap was aligned along the biting direction due to the applied biting stress. This result clearly represents Bap alignment is the parameter which can sensitively reflect the in vivo stress distribution.(3) In the case of non-biting beagle mandible, quite different distribution of the bone density and BAp alignment was found. The lack of biting stress induced more homogenous distribution of bone density and Bap alignment.We conclude that the change in the bone density and the BAp alignment is closely related to the degree of growing and in vivo stress distribution due to the biting. The BAp texture is sensitively controlled depending on the local stress distribution, as a result, bone tissue can exhibit effective mechanical function against the mechanical environment.

本实验主要研究了生长和咬合应力对大鼠和比格犬下颌骨质量和数量的影响。分析咬合力对咬合动物和非咬合动物牙根正下方的影响。通过拔牙获得不咬动物。利用基于X射线衍射的新技术分析了生物磷灰石（BAp）c轴择优取向作为骨质量参数的可能性，并对骨组织的体积和密度等常规参数进行了评价。本研究取得了以下结果。(1)大鼠和比格犬的皮质骨截面积均随生长而单调增加。骨密度和Bap配向的增加早于皮质区，且随位置的不同，骨密度和Bap配向的分布有明显差异。(2)在下颌骨中，Bap一般沿近远中轴沿着单向排列，而在牙根下方，Bap由于咬合应力的作用，沿咬合方向沿着排列。这一结果清楚地表明Bap排列是能够灵敏地反映体内应力分布的参数。(3)在非咬合状态下，骨密度和BAp排列的分布与咬合状态下的骨密度和BAp排列有很大的不同，咬合应力的缺乏导致骨密度和BAp排列的分布更加均匀，我们认为骨密度和BAp排列的变化与咬合引起的生长程度和体内应力分布密切相关。BAp织构根据局部应力分布而被敏感地控制，因此，骨组织可以针对机械环境表现出有效的机械功能。