Analysis of change in mandible bone microstructure induced by masticatory malfunction from a viewpoint of crystallography

下颌骨是通过膜内骨化过程形成的，具有组织良好的微观结构，由优先排列的胶原蛋白组成。/生物磷灰石（BAp），具有承受主要来自咬合的复杂机械应力的作用。本研究旨在通过微束XRD、pQCT和一些特定的动物模型：控制咬咬应力和拔牙、骨代谢、营养紊乱和原发性骨质疏松，阐明Col./ BAp优先排列与骨力学性能的关系。本研究将从骨结构和功能的角度为设计新型种植体提供指导。

Mandible, which is formed through intramembranous ossification process, has a well-organized micro-structure comprising preferentially-aligned collagen(Col.)/ biological apatite(BAp) and has a role to bear complicated mechanical stress mainly from biting. The present study is aiming at clarifying the correlation between the preferential alignment of Col./ BAp and mechanical properties of bone by using a microbeam XRD, pQCT and some specific animal models : controlled biting stress and dental extraction, bone metabolism, nutrient disturbance and primary osteoporosis. The present study will provid a direction for designing novel dental implant from a viewpoint of bone microstructure and function.