Effects of LHRH analogues on the ultrastructure of male rat pituitary gonadotropes
Effects of LHRH analogues on the ultrastructure of male rat pituitary gonadotropes
批准号:
18590177
负责人:
WATANABE Tsuyoshi
金额:
$2.66万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2008
中文摘要
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英文摘要
前立腺癌等に対するホルモン治療薬として実用化されているLHRH誘導体のうち、本研究では、代表的なLHRHアゴニストであるleuprorelinの持続投与で生じる性腺刺激ホルモン産生細胞の微細構造の経時的変化を解析した。その結果、同剤投与開始直後に発揮される強力な分泌促進作用と慢性効果であるLHRH受容体の不応化誘導の相乗作用で、同細胞からのゴナドトロピン分泌が強力かつ効率的に抑制されることが明らかになった。
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実験内分泌学的アプローチを活用した細胞内過程の解析
使用实验内分泌学方法分析细胞内过程
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[渡部剛, 他]
通讯作者:
他
A large form of secretogranin lll functions as a sorting receptor for chromogranin A aggregates in PC12 cells
大量的分泌粒蛋白 III 在 PC12 细胞中充当嗜铬粒蛋白 A 聚集体的分选受体
DOI:
--
发表时间:
2008
期刊:
Mol Endocrinol 22
影响因子:
--
作者:
[HanL., et.al.]
通讯作者:
et.al.
神経・内分泌細胞における分泌蛋白の動線の再考-ゴルジ装置の極性が示すもの-平義樹ゴルジ装置と物質輸送のイメージング
重新考虑神经和内分泌细胞中分泌蛋白的流动线 - 高尔基体的极性表明什么 - Yoshiki Taira 成像高尔基体和物质运输
DOI:
--
发表时间:
2006
期刊:
影响因子:
--
作者:
[渡部剛, 穂坂正博, 阪井裕子, 平義樹]
通讯作者:
平義樹
実験内分泌学的アプローチを活用した細胞内過程の解析細胞内輸送と代謝
使用实验内分泌学方法分析细胞内过程细胞内运输和代谢
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[渡部剛, 阪井裕子, 暮地本宙己]
通讯作者:
暮地本宙己
内分泌細胞における分泌顆粒形成とそれに係わるグラニン蛋白と脂質ラフトの役割分泌現象と生体膜、そしてその可視化
内分泌细胞中分泌颗粒的形成以及颗粒蛋白和脂筏在其中的作用分泌现象、生物膜及其可视化
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[渡部剛, 阪井裕子, 穂坂正博]
通讯作者:
穂坂正博
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