Study on self-regeneration of the central nervous system by perineuronal progenitor cell

神经周围祖细胞对中枢神经系统自我再生的研究

• 批准号: 18590191
• 负责人: KATAOKA Yosuke
• 金额: $ 2.21万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590191/
• 关键词: perineuronal progenitor cell; proliferation; differentiation; central nervous system; cerebral cortex; oligodendrocyte; repair; progenitor cell; Perineuronal germinal cell; 脱分極波; Spreading depression; Perineuronal satellite cell; 再生; 脱分極

In the rat cerebral cortex, cells which exist around neuronal cell somata and have a potent proliferative activity were found. We named the cells "perineuronal progenitor cells". The perineuronal progenitor cells differentiated into immature inhibitory neurons and astrocytes as well as oligodendrocytes, under physiological condition. The cells showed the facilitation of proliferation under neuronal degeneration or excessive excitation of neurons. These results indicated that the perineuronal progenitor cells play an important role in tissue repair of the central nervous system.We explored substances which induce proliferation or differentiation of the perineuronal progenitor cells by using a DNA mic roarray system, and could find some substances. The number of the perineuronal progenitor cells decreased in aged animals. This phenomenon suggests that the cells are involved in atrophy of the brain or cognitive disfunction. More studies on the cells will bring about new concepts on mechanism of the occurrence of neurological disorders.

在大鼠大脑皮层中发现了存在于神经元胞体周围的具有强烈增殖活性的细胞，我们将其命名为“神经元周祖细胞”。在生理条件下，神经元周祖细胞可分化为未成熟的抑制性神经元、星形胶质细胞和少突胶质细胞。神经元变性或神经元过度兴奋时，细胞表现出增殖促进作用。这些结果表明，神经束膜前体细胞在中枢神经系统的组织修复中起着重要的作用，我们利用DNA微阵列系统探索了诱导神经束膜前体细胞增殖或分化的物质，并发现了一些物质。老年动物神经元周祖细胞数量减少。这种现象表明，这些细胞与大脑萎缩或认知功能障碍有关。对这些细胞的进一步研究将为神经系统疾病的发生机制带来新的概念。

项目成果

Studies on molecular and neural mechanisms of fatigue using animal models for fatigue

利用疲劳动物模型研究疲劳的分子和神经机制

• 发表时间: 2008

MicroPETを用いた片頭痛病態モデルの評価

使用 MicroPET 评估偏头痛病理模型

• 发表时间: 2007
• 作者: 崔 翼龍;和田 康弘;大和 正典;田村 泰久;片岡 洋祐;渡辺 恭良
• 通讯作者: 渡辺 恭良

各種疲労モデル動物を用いた疲労の分子・神経メカニズム研究の概要(シンポジウム)

使用各种疲劳模型动物进行疲劳的分子和神经机制研究综述（研讨会）

• 发表时间: 2008
• 作者: 片岡 洋祐;大和 正典;金光 華;渡辺 恭良
• 通讯作者: 渡辺 恭良

Effects of (-)-epigallocatechin gallate in liver of an animal model of combined (physical and mental) fatigue

• DOI: 10.1016/j.nut.2008.03.001
• 发表时间: 2008-06-01
• 期刊: NUTRITION
• 影响因子: 4.4
• 作者: Tanaka, Masaaki;Baba, Yoshitake;Watanabe, Yasuyoshi
• 通讯作者: Watanabe, Yasuyoshi

Control of Neural activity and metabolism using low-reactive level laser

使用低反应水平激光控制神经活动和新陈代谢

• 发表时间: 2008
• 作者: Kataoka;Y.;et. al.
• 通讯作者: et. al.