Functional analysis of the voltage-dependent calcium channel β subunit in cardiac myocyte

利用基因操作小鼠，我们评价了电压依赖性钙通道β亚基在交感神经调节系统中的重要性。为探讨电压依赖性钙通道β亚基在交感神经调控中的作用，我们制备了电压依赖性钙通道β亚基缺失和过表达转基因小鼠。空突变小鼠的交感神经张力显著降低，而过表达小鼠的神经张力增加，表明β亚基在交感神经控制系统中的重要性。

Using gene-manipulated mice, we evaluated importance of voltage-dependent calcium channel β subunit in sympathetic nerve regulation system.It is well known, that cardiac myocytes are regulated by sympathetic nerve system through voltage-dependent calcium channel. To evaluate the importance of the voltage-dependent calcium channel β subunit in the sympathetic nerve control, we made null-mutant and overexpression transgenic mice of β subunit. The null-mutant showed significantly decreased sympathetic nerve tonus, while the overexpression mice revealed increased nerve tonus, indicating the importance of the β subunit in the sympathetic nerve control system.