Analysis of mechanism of IL-12 induction from macrophage stimulated by the mutant of Escherichia coli enterotoxin
Analysis of mechanism of IL-12 induction from macrophage stimulated by the mutant of Escherichia coli enterotoxin
批准号:
18590440
负责人:
TSUJI Takao
金额:
$2.62万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2008
中文摘要
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英文摘要
ETECのLTの変異体(mLT)は、志賀毒素2または死菌BCGに対するTh2またはTh1系T細胞を活性化すること、mLTはマクロファージ(Mφ)からのIL-12とTNFα産生を促進することを明らかにした。上昇したTNFαはIL-12産生促進の上流に存在していたが、NF-κおよびJNK経路の活性化はなかった。そこで、CREBを介してTh2系T細胞を活性化が予想されているコレラ毒素とmLTを比較検討し、mLT特有の細胞内情報伝達機構の解析を進めている。
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Isolation of a human antibody with strong neutralizing activity against disphtheria toxin.
分离出对白喉毒素具有强中和活性的人抗体。
DOI:
--
发表时间:
2006
期刊:
Infect. Immun. 74
影响因子:
--
作者:
[Kakita M, Tsuji, T et al.]
通讯作者:
T et al.
DOI:
10.1111/j.1574-6968.2006.00134.x
发表时间:
2006-03-01
期刊:
FEMS MICROBIOLOGY LETTERS
影响因子:
2.1
作者:
[Kobayashi, H, Takahashi, E, Okamoto, K]
通讯作者:
Okamoto, K
Mutant Escherichia coli enterotoxin as a mucosal adjuvant induces specific Thl responses of CD4(+)and CD8(+)T cells to nasal killed-bacillus calmette-guerin in mice.
突变型大肠杆菌肠毒素作为粘膜佐剂诱导小鼠CD4(+)和CD8(+)T细胞对鼻腔灭活卡美特-格林杆菌的特异性Thl反应。
DOI:
--
发表时间:
2006
期刊:
Vaccine 24
影响因子:
--
作者:
[Takahashi H, Tsuji, T et al.]
通讯作者:
T et al.
標準微生物学第10版(山西弘一、平松啓一、中込治編)細菌の病原因子
标准微生物学第10版(山西浩一、平松庆一、中込修主编)细菌致病因素
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ochi S, Arimitsu H, Tsukamoto K, Ohtani K, Sasaki K, Shigemori N, Kato M, Shimizu T and Tsuji T., 辻孝雄]
通讯作者:
辻孝雄
Enhanced mucosal immunogenicity of prion protein following fusion with B subunit of Escherichia coli heat-labile enterotoxin
朊病毒蛋白与大肠杆菌不耐热肠毒素 B 亚基融合后增强粘膜免疫原性
DOI:
--
发表时间:
2006
期刊:
Vaccine 24(15)
影响因子:
--
作者:
[Yamanaka H, Ishibashi D, Yamaguchi N, Yoshikawa D, Nakamura R, Okimura N, Arakawa T, Tsuji T, Katamine S, Sakaguchi. S.]
通讯作者:
Sakaguchi. S.
共 24 条
Frequency Control in Microgrid using Decentralized Disturbance Observer
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Isolation of humonal monoclonal antibody cross-reactively neutralizing against shiga toxin type 1 and 2 and treating a patient suffering HUS
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A cooperative operation method of power and water systems
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批准号:23656193
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财政年份:2011
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A Study on Autonomous Decentralized Voltage Profile Control Method in Future Distribution Network considering Control Priority
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批准号:21760214
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.41万
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财政年份:2009
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Subunit vaccine for Tbc with mucosal adjuvant activity of LT
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批准号:21590497
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2009
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Autonomous Decentralized Control Method of Future Distribution Network considering Time-Delay
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批准号:19860035
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资助金额:$1.66万
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财政年份:2007
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依托单位:
A mutant of Escherichia coli enterotoxin inducing a specific Tb1-type of T cells to varicella-zoster vaccine enhances the production of IL-12 by IFNγ-stimulated macrophages
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批准号:15590403
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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Isolation of enterotoxigenic Pseudomonas fluorescens from Asia region
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批准号:14406008
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.47万
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财政年份:2002
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负责人:TSUJI Takao
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依托单位:
Analysis of adjuvant action Escherichia coli enterotoxin
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批准号:13670285
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依托单位:
Analysis of a fuctor involving trnslocation of LT to the cell.
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批准号:09670302
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财政年份:1997
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负责人:TSUJI Takao
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依托单位:
Analysis of the relationship between ARF and cholera toxin and LT
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批准号:06670308
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1994
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负责人:TSUJI Takao
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依托单位:
Analysis of the mechanism of the invasion of the A subunit of heat-labile enterotoxin from enterotoxigenic E coli
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批准号:03670225
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资助金额:$1.22万
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财政年份:1991
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依托单位:
Basic and Clinical Studies on the Mechanism of Liver Cell Necrosis in Hepatits Type B
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1989
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负责人:TSUJI Takao
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依托单位:
Analysis of the Active Site of the A Subunit of LT Produced by Enterotoxigenic E Coli
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批准号:01570235
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1989
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负责人:TSUJI Takao
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依托单位: