Subunit vaccine for Tbc with mucosal adjuvant activity of LT

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Ag85A, B or C of BCG and CFP-10, EAST-6, PPE or TB7.3 of Tbc were overproduced and purified. Although TB7.3 was aggregated and could not be purified, the others were purified and used for antigens to immunize mice with mutant LT as the mucosal adjuvant. We determined that the mice immunized with Ag85A, B or C plus mLT were not effective for prevention of BCG or Tbc infection. As we need much time to determine whether CFP-10, EAST-6, PP E or TB7.3 from Tbc will be effective to Tbc infection as the vaccine, we are doing some experiments to determine it.