The analysis of the mechanism for tissue specificity autoimmune

组织特异性自身免疫机制分析

• 批准号: 18590473
• 负责人: KURODA Noriyuki
• 金额: $ 2.5万
• 依托单位: Tsurumi University (2007)The University of Tokushima (2006)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590473/
• 关键词: autoimmune; diabetes; NOD mouse; AIRE; 胸腺上皮細胞; 臓器特異性

We established NOD background Aire deficient mice. All of the case, they have the growth problems until 7-8 weeks old. Using pathologenetic analysis, we can't find the insulitis from these mice's pancreas, but heavy inflammatory in acinus region around the islet of Langerhans. About 6% of Aire^<+/+> NOD mice developed the diabetes until 20 weeks old but we couldn't find any diabetes from Aire^+ NOD mice. In order to evaluate that Aire^+ NOD mice are intrinsically resistant to the development of diabetes, we used an induced diabetes model. We treated the mice with Cyclophosphamide (CY), which accelerates to develop diabetes in NOD mice. Most of the control Aire^<+/+> NOD mice develop the diabetes between 11 and 27 days after the injection of CY. But on the Aire+ NOD mice, there is no mice developed diabetes. These results strongly suggest Aire^+ NOD mice have the registration against developing diabetes.

我们建立了点头背景AIRE不足的小鼠。所有情况下，他们都有增长问题，直到7-8周大。使用病理学分析，我们找不到这些小鼠胰腺的胰岛炎，但是在兰格汉胰岛周围的刺激性区域的炎症性重量。大约6％的AIRE^<+/+>点头小鼠直到20周大，但我们找不到来自AIRE^+NOD小鼠的任何糖尿病。为了评估AIRE^+ NOD小鼠对糖尿病的发育本质上具有抗性，我们使用了诱导的糖尿病模型。我们用环磷酰胺（CY）治疗小鼠，该小鼠加速了在NOD小鼠中发展糖尿病。大多数对照AIRE^<+/+>点头小鼠在注射CY后11至27天之间会发展出糖尿病。但是在AIRE+点头小鼠上，没有小鼠患有糖尿病。这些结果强烈表明AIRE^+ NOD小鼠具有针对糖尿病的注册。

项目成果

Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology

• DOI: 10.1073/pnas.0709345105
• 发表时间: 2008-05-06
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Matsumoto, Mitsuru;Zhou, Yiqing;Chaplin, David D.
• 通讯作者: Chaplin, David D.

Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice

• DOI: 10.1172/jci26971
• 发表时间: 2006-05-01
• 期刊: JOURNAL OF CLINICAL INVESTIGATION
• 影响因子: 15.9
• 作者: Niki, S;Oshikawa, K;Matsumoto, M
• 通讯作者: Matsumoto, M

Essential Role of I_k B Kinase(IKK) α in Thymic Organogenesis Required for the Establishment of Self-Tolerance

I_k B 激酶 (IKK) α 在建立自我耐受所需的胸腺器官发生中的重要作用

• 发表时间: 2006
• 期刊: The Journal of Immunology 176
• 作者: Dan Kinoshita;Fumiko Hirota;Tsuneyasu Kaisho;Michiyuki Kasai;Keisuke Izumi;Yoshimi Bando;Yasuhiro Mouri;Akemi Matsushima;Shino Niki;Hongwei Han;Kiyotaka Oshikawa;Noriyuki Kuroda;Masahiko Mae gawa;Minoru Irahara;Kiyosbi Takeda;Shizuo Akira
• 通讯作者: Shizuo Akira