Analysis of vascular endothelial cell differentiation and growth system in the rat tongue inflammation model.

大鼠舌炎症模型中血管内皮细胞分化和生长系统分析

• 批准号: 21592348
• 负责人: KURODA Noriyuki
• 金额: $ 2.83万
• 依托单位: Tsurumi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592348/
• 关键词: 口腔解剖学(含組織学・発生学); 舌炎; LPS; アデノシンレセプター; 抗原提示細胞

To make the model of tongue inflammation, inject the LPS with incomplete Freund's adjuvant. About 8days after the injection, the luminal areas of blood vessels were increased. But inject antagonists of adenosine receptors before to inject the LPS and incomplete Freund's adjuvant, the ratio of blood vessels in the lingual tissue was remarkably reduced. These results show that adenosine receptors are very important roll of vascular endothelial growth.

为了使舌头炎症模型，将LPS注入不完整的Freund佐剂。注射后约8天，增加了血管的管腔区域。但是，注入腺苷受体的拮抗剂注入LPS和不完整的Freund辅助物，舌组织中血管的比例明显降低。这些结果表明，腺苷受体是血管内皮生长的非常重要的卷。

项目成果

Angiogenesis by VEGF released from antigen-presenting cells during the course of LPS-induced glossitis of rats.

在 LPS 诱导的大鼠舌炎过程中，抗原呈递细胞释放 VEGF 导致血管生成。

• 发表时间: 2009
• 作者: Hara Yaiko;et al.
• 通讯作者: et al.

Up-regulation of vascular endothelial growth factor expression by adenosine through adenosine A2 receptors in the rat tongue treated with endotoxin

• DOI: 10.1016/j.archoralbio.2009.07.008
• 发表时间: 2009-10-01
• 期刊: ARCHIVES OF ORAL BIOLOGY
• 影响因子: 3
• 作者: Hara, Yaiko;Kuroda, Noriyuki;Sato, Tetsuji
• 通讯作者: Sato, Tetsuji

舌炎モデルを用いた脈管形成機構の解析

利用舌炎模型分析血管生成机制

• 发表时间: 2010
• 作者: 美島健二;井上裕子;坪田一男;斎藤一郎;原矢委子
• 通讯作者: 原矢委子

An endogenous signal for dendritic cell maturation evaluated in the inflammatory lingual tissue of rats

在大鼠炎症舌组织中评估树突状细胞成熟的内源信号

• 发表时间: 2009
• 作者: 原矢委子;黒田範行;佐藤哲二
• 通讯作者: 佐藤哲二

Immunocompetent cells and cytokine expression in the rat periodontal ligament at the initial stage of orthodontic tooth movement

• DOI: 10.1016/j.archoralbio.2010.11.010
• 发表时间: 2011-05-01
• 期刊: ARCHIVES OF ORAL BIOLOGY
• 影响因子: 3
• 作者: Baba, Shunsuke;Kuroda, Noriyuki;Sato, Tetsuji
• 通讯作者: Sato, Tetsuji