Investigative of diffentiation of pancreatic cells and application for treatments for chronic pancreatitis

在E15时，在胰腺组织中证实了锯齿状蛋白1的出现。制备了5只胰腺特异性Jaggedl-floxed基因敲除小鼠。jaggedl floxed敲除小鼠，证实了其中产生淀粉酶分泌功能以及分泌胰岛素和胰高血糖素的细胞。部分外分泌组织转变为脂肪组织

Appearance of Jagged1 was confirmed in pancreatic tissue at E15. 5 Pancreas-specific Jaggedl-floxed knock-out mice were made.In pancreas-specific. jaggedl floxed knock-out mice, the cells in which function of amylase secretion was made and secretion of insulin and glucagon were demonstrated. In part, exocrine tissues were changed to fatty tissues