Investigative of diffentiation of pancreatic cells and application for treatments for chronic pancreatitis

胰腺细胞分化的研究及其在慢性胰腺炎治疗中的应用

• 批准号: 18590750
• 负责人: MINE Tetsuya
• 金额: $ 2.49万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590750/
• 关键词: Noctch; Transgenicmouse; D111; Jagged; exocrine; endocrine; knockout mouse; Ptfla-Cre; トランスジェニックマウス; Jagged; 外分泌細胞; 内分泌細胞; 膵; Dll1; Pdx-Cre; ER; 膵幹細胞; リガンド

Appearance of Jagged1 was confirmed in pancreatic tissue at E15. 5 Pancreas-specific Jaggedl-floxed knock-out mice were made.In pancreas-specific. jaggedl floxed knock-out mice, the cells in which function of amylase secretion was made and secretion of insulin and glucagon were demonstrated. In part, exocrine tissues were changed to fatty tissues

E15时胰腺组织中证实了Jagged1的出现。制备了5只胰腺特异性Jaggedl-floxed敲除小鼠。在胰腺特异性中。 jaggedl floxed基因敲除小鼠，其细胞具有淀粉酶分泌功能以及胰岛素和胰高血糖素分泌功能。部分外分泌组织转变为脂肪组织

项目成果

Clinical and pathological features of a prolonged type of acute intrahepatic cholestasis

• DOI: 10.1111/j.1872-034x.2007.00115.x
• 发表时间: 2007-08
• 期刊: Hepatology Research
• 影响因子: 4.2
• 作者: N. Watanabe;S. Takashimizu;Sei‐ichiro Kojima;T. Kagawa;Y. Nishizaki;T. Mine;S. Matsuzaki

Is post-endoscopic retrograde cholangiopancreatography pancreatitis the same as acute clinical pancreatitis?

内镜逆行胰胆管造影术后胰腺炎与急性临床胰腺炎相同吗？

• 发表时间: 2007
• 期刊: J Gastroenterol 42
• 作者: Suzuki J;Ogawa M;Kosuge H;Takayama K;Isobe M.;Mine T
• 通讯作者: Mine T

Reconsidering the increase of expression of GGT in alcoholic liver diseases

重新考虑酒精性肝病中 GGT 表达的增加

• 发表时间: 2007
• 期刊: Hepatol res 37
• 作者: Suzuki J;Ogawa M;Isobe M.;Mine T.
• 通讯作者: Mine T.

消化器病シークレット

消化系统疾病的秘密

• 发表时间: 2007
• 作者: 峯徹 哉;幕内 博康
• 通讯作者: 幕内 博康

Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells

• DOI: 10.1152/ajpgi.00367.2007
• 发表时间: 2008-01-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
• 影响因子: 4.5
• 作者: Kagawa, Tatehiro;Watanabe, Norihito;Mine, Tetsuya
• 通讯作者: Mine, Tetsuya