New autocrine agent in hepats cytes and its role

在此之前，我首先论证了激活素A在肝脏代谢中的重要作用。因此，除了对肝脏代谢的影响外，我开始认识激活素A的作用。首先，证实激活素A抑制肝细胞的增殖。第二，激活素A似乎是由肝细胞产生的，肝细胞有自己独特的受体和丝氨酸酶。此外，我们还证实了肝细胞中激活素A的siPAL转导，激活素A激活了磷脂酶Cr并促进了三磷酸肌醇的产生。因此，激活素A可增加胞浆游离钙浓度。这些信号转导系统被百日咳毒素阻断。

I firstly demonstrated that activin A plays a important role in hepatic metabolism, previously. There fore, I started to identify the role of activin A except the effect of hepatic metabolism. Firstly, it was demonstrated that activin A inhibits the proliferation of hepats cytes. Second, activin A seems to be produced by hepatscyles and hepatscytes possesses own specific receptor and sercne thieome hinase. Furthermore, we demonstrated sipal trans duction of activin A in hepatscytes, Activin A activates Phospholipase Cr and promotes the production of inositol tris phosyhates. So, activin A increases the cytsplasmi free calcium concentration. These signal transduction systems were blocked by pertussis toxin.