Gene Transfer of Human Extracellular Superoxide Dismutase Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats

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In the present study, we examined whether intratracheal gene transfer of human extracellular superoxide dismutase (ECSOD) could ameliorate monocrotaline (MCT)-induced PAH in rats. MCT-injected rats were concomitantly intratracheally administered vehicle (MCT group), an adenovirus expressing β-galactosidase (Adβgal group), or human ECSOD (AdECSOD group). Twenty-eight days after the MCT injection, right ventricular systolic pressure and the weight ratio of the right ventricle to the left ventricle plus septum were significantly lower in the AdECSOD group. As the mechanism of these effects, 8-isoprostane in lung tissue was significantly reduced in the AdECSOD group. ECSOD overexpression to the lung ameliorated MCT-induced PAH in rats.