Effects of maternal care on brain development : molecular mechanism of mother-infant interactions

Wistar雄性大鼠在PND10~15期间与母亲分离3h/d(MD组)。分析神经营养因子配体和受体的表达。MD大鼠脑源性神经营养因子/TrkB在mRNA和蛋白水平的表达均增强。而NGF/TrkA的表达水平在两组间无显著差异。另一方面，OMGp在MD动物中的表达升高。这些营养因子的异常波动会引起器质性变化，最终导致功能障碍。

Wistar male rats were separated from their mothers for 3 hours each day between PND10 and 15 (MD group). Nurotrophin ligand and receptor expressions were analyzed. The expression of BDNF/TrkB in MD rats was enhanced in both mRNA and protein levels. In contrast, no significant difference in NGF/TrkA expression level was observed between these groups. On the other hand, OMgp expression was elevated in MD animals. Abnormal fluctuations in those trophic factors cause organic changes, and ultimately lead to functional disturbance.