Ethiological mechanisms of perinatal stress on lifestyle-related diseases pathogenesis

围产期应激与生活方式相关疾病发病机制

• 批准号: 22591203
• 负责人: MIKI Takanori
• 金额: $ 3.08万
• 依托单位: Kagawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591203/
• 关键词: 脳発達; 母仔分離ストレス; 神経栄養因子; 生活習慣病; 脂肪組織; エネルギー代謝; ミトコンドリア; 肥満; 周生期ストレス; 脳; セロトニン; 神経栄養因子受容体; 脂肪細胞; UCP-1; 代謝; 環境-遺伝子相互作用; DNAメチル化; エピジェネティク

This study was carried out to examine the effects of early postnatal maternal separation stress on the brain development, biological properties of adipose tissue, and the interactions between them. Wistar rats were separated from their mothers in early life. The level of various neurotrophic factor ligands/receptors in the cerebral cortex and cerebellum showed abnormal time-dependent fluctuations. Given that these factors play important roles in brain development, it can be speculated that the altered expression of these factors induced by maternal separation may interrupt normal brain development and ultimately lead to functional disruption. Furthermore, there was a significant change in the level of various mitochondrial energy-expenditure molecules. Given that these molecules influence the mitochondrial metabolism, our study indicates that early postnatal maternal deprivation can influence the fate of adipose tissue proliferation, presumably leading to obesity later in life.

本研究旨在探讨产后早期母体分离应激对脑发育和脂肪组织生物学特性的影响及其相互关系。Wistar大鼠在生命早期就与其母亲分开。大脑皮层和小脑中各种神经营养因子配体/受体的水平呈异常的时间依赖性波动。鉴于这些因素在大脑发育中起着重要作用，可以推测，由母体分离诱导的这些因素的表达改变可能会中断正常的大脑发育，并最终导致功能中断。此外，各种线粒体能量消耗分子的水平也发生了显著变化。鉴于这些分子影响线粒体代谢，我们的研究表明，出生后早期的母亲剥夺可以影响脂肪组织增殖的命运，可能导致以后的肥胖。

项目成果

生後早期の母仔分離ストレスにより惹起される小脳神経栄養因子/受容体発現レベルの変動

早期母婴分离应激诱导小脑神经营养因子/受体表达水平的变化

• 发表时间: 2010
• 作者: 白石直樹、中島崇、山田重人、高桑徹也;他;田中 英高.;小川哲郎;三木崇範
• 通讯作者: 三木崇範

Differential effects of neonatal maternal separation on the expression of neurotrophic factors in rat brain. II: Regional differences in the cerebellum versus the cerebral cortex.

新生儿母体分离对大鼠脑神经营养因子表达的差异影响。

• 发表时间: 2013
• 期刊: Okajimas Folia Anat Jpn.
• 作者: Miki T;Lee KY;Yokoyama T;Liu JQ;Kusaka T;Suzuki S;Ohta K;Warita K;Jamal M;Ueki M;Yakura T;Hosomi N;Takeuchi Y.
• 通讯作者: Takeuchi Y.

生後早期の母仔分離ストレスにより惹起される神経栄養因子/受容体発現レベルの変動(第2報)

早期母婴分离应激引起的神经营养因子/受体表达水平的变化（第二次报告）

• 发表时间: 2012
• 作者: 三木崇範;ら
• 通讯作者: ら

Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain.

• DOI: 10.1186/1750-1326-6-8
• 发表时间: 2011-01-21
• 期刊: Molecular neurodegeneration
• 影响因子: 15.1
• 作者: Bellinger FP;Bellinger MT;Seale LA;Takemoto AS;Raman AV;Miki T;Manning-Boğ AB;Berry MJ;White LR;Ross GW
• 通讯作者: Ross GW

Short-term ethanol exposure causes imbalanced neurotrophic factor allocation in the basal forebrain cholinergic system: a novel insight into understanding the initial processes of alcohol addiction.

短期乙醇暴露导致基底前脑胆碱能系统神经营养因子分配失衡：了解酒精成瘾初始过程的新见解。

• DOI: 10.1007/s00702-013-1085-y
• 发表时间: 2014
• 期刊: J Neural Transm.
• 作者: Miki T;Kusaka T;Yokoyama T;Ohta K;Suzuki S;Warita K;Jamal M;Wang ZY;Ueki M;Liu JQ;Yakura T;Tamai M;Sumitani K;Hosomi N;Takeuchi Y.
• 通讯作者: Takeuchi Y.