Ethiological mechanisms of perinatal stress on lifestyle-related diseases pathogenesis

本研究旨在探讨产后早期母亲分离应激对脑发育、脂肪组织生物学特性的影响及其相互作用。Wistar大鼠在幼年时与它们的母亲分开。大脑皮层和小脑内各种神经营养因子配体/受体水平呈现异常的时变波动。鉴于这些因子在大脑发育中发挥着重要的作用，我们可以推测，母亲分离导致的这些因子表达改变可能会中断正常的大脑发育，最终导致功能破坏。此外，各种线粒体能量消耗分子的水平也发生了显著变化。鉴于这些分子影响线粒体代谢，我们的研究表明，产后早期母体剥夺可以影响脂肪组织增殖的命运，可能导致以后的肥胖。

This study was carried out to examine the effects of early postnatal maternal separation stress on the brain development, biological properties of adipose tissue, and the interactions between them. Wistar rats were separated from their mothers in early life. The level of various neurotrophic factor ligands/receptors in the cerebral cortex and cerebellum showed abnormal time-dependent fluctuations. Given that these factors play important roles in brain development, it can be speculated that the altered expression of these factors induced by maternal separation may interrupt normal brain development and ultimately lead to functional disruption. Furthermore, there was a significant change in the level of various mitochondrial energy-expenditure molecules. Given that these molecules influence the mitochondrial metabolism, our study indicates that early postnatal maternal deprivation can influence the fate of adipose tissue proliferation, presumably leading to obesity later in life.