An association study of the cytokine genes in patients with schizophrenia.

精神分裂症患者细胞因子基因的关联研究。

• 批准号: 18591316
• 负责人: YONEDA Hiroshi
• 金额: $ 2.26万
• 依托单位: Osaka Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591316/
• 关键词: Schizophrenia; Association study; IL-2; IL-4; TGF-betal; TGF-betal

Background: Schizophrenia has been hypothesized as a neuro-developmental disorder. A number of anatomical alternations in neuro-pathological and neuro-imaging studies have supported this theory. Various cytokine plays an important role for the development of central nervous system. The Helper T cell cytokine (Th cytokine) expression levels are altered in patients with schizophrenia. We investigated the association between IL-2 rs2069762, IL4 rs2243250, TGF-beta1 rs4803455, TGF-beta1 rs2241716, TGF-beta1 rs1800469 and schizophrenia in Japanese.Methods : The subjects were 193 patients with schizophrenia, 69 patients with atypical psychosis and 123 normal control. Genomic DNA was isolated from whole blood. The genotyping of cytokine genes were examined by the fluorescence resonance energy transfer method.Results: As a result of analysis, the frequencies of IL-2 rs2069762, IL4 rs-2243250, TGF-beta1 rs4803455, TGF-beta1 rs1800469 between schizophrenia group, atypical psychosis group and normal control group showed no differences. TGF-beta1 rs2241716 polymorphism was associated with atypical psychosis.Conclusion: Our results suggest that TGF-beta1 rs2241716 polymorphisms might be involved in vulnerability of atypical psychosis.

背景：精神分裂症被认为是一种神经发育障碍。神经病理学和神经影像学研究中的一些解剖学变化支持了这一理论。各种细胞因子对中枢神经系统的发育起着重要的作用。精神分裂症患者辅助性T细胞因子（Th细胞因子）表达水平改变。我们研究了IL-2 rs 2069762、IL-4 rs 2243250、TGF-β 1 rs 4803455、TGF-β 1 rs 2241716、TGF-β 1 rs 1800469与日本精神分裂症的关系。从全血中分离基因组DNA。结果：IL-2 rs 2069762、IL-4 rs 2243250、TGF-β 1 rs 4803455、TGF-β 1 rs 1800469基因型在精神分裂症组、不典型精神病组和正常对照组之间的频率差异无统计学意义。结论：TGF-β 1基因rs 2241716多态性可能与非典型精神病易感性有关。

项目成果

Aripiprazole投与ラット脳におけるApoptosis関連cytokine mRNA発現量の変化

阿立哌唑治疗大鼠脑内凋亡相关细胞因子 mRNA 表达的变化

• 发表时间: 2006
• 期刊: 神経化学 45(2-3)
• 作者: Tsutsumi;A.;Masaki;N.;Kikuyams;H.;Yondea;H.;et. al.;Kanazawa Tetsufumi;堤 淳;菊山 裕貴
• 通讯作者: 菊山 裕貴

アルツハイマー病におけるTNF-α遺伝子プロモーター領域のSNP解析

阿尔茨海默病TNF-α基因启动子区的SNP分析

• 发表时间: 2006
• 期刊: 神経化学 45(2-3)
• 作者: Tsutsumi;A.;Masaki;N.;Kikuyams;H.;Yondea;H.;et. al.;Kanazawa Tetsufumi;堤 淳
• 通讯作者: 堤 淳

Association study of TGF betal gene polymorphisms with schizophrenia.

TGFβ基因多态性与精神分裂症的关联研究

• 发表时间: 2007
• 作者: Kikuyama;H.;Tsutsumi;A.;Nishiguchi;M.;Yoneda;H.;et. al.
• 通讯作者: et. al.

非定型精神病の遺伝子

非典型精神病的基因

• 发表时间: 2007
• 期刊: 精神科 11
• 作者: 堤 淳;西口 昌樹;菊山 裕貴;米田 博
• 通讯作者: 米田 博

Alterations in IL-4, STAT6 mRNA expression levels in schizophrenia.

精神分裂症中 IL-4、STAT6 mRNA 表达水平的变化。

• 发表时间: 2007
• 作者: Hokyo;A. Tsutsumi;A.;Nishiguchi;M.;Yoneda H.;et. al.
• 通讯作者: et. al.