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Association Study of Orofacial Cleft Risk Variants across All of Us Cancer Diagnoses

Association Study of Orofacial Cleft Risk Variants across All of Us Cancer Diagnoses
所有癌症诊断中口面裂风险变异的关联研究
批准号：
10654330
负责人：
Mary L. Marazita
金额：
$11.81万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
项目状态：
已结题
起止时间：
2022-08-15 至 2023-03-31
来源：
https://reporter.nih.gov/project-details/10654330
关键词：
AddressAdministrative SupplementBehavior TherapyChildCleft LipDataData SetDentalFaceGenesGeneticGenetic RiskGoalsGrantHumanIndividualInfant MortalityInterventionLifeLive BirthMalignant NeoplasmsMedicalNutritionalOperative Surgical ProceduresPalatePublic HealthRisk FactorsSpeechStructural Congenital AnomaliesTreatment CostVariantcancer diagnosiscancer riskcomorbiditydata harmonizationfeedinggenetic architecturehealth economicshigh riskmortalityorofacial cleftparent grantrisk variant

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ABSTRACT This new grant is a Revision/Administrative Supplement to parent grant R03-DE032062. It has long been noted that individuals with orofacial clefts (OFCs) and their unaffected relatives have a higher risk of certain cancers. The hypothesis of this revision is that the association between OFC and cancer is in part due to genetic commonalities. In this Revision, we will investigate possible associations between OFC genetic risk variants with the cancer diagnoses in All of Us.
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Genomic Risk Variants in Orofacial Clefting: Discovery and Functional Validation
Differences between the sexes among genetic variants affecting orofacial cleft birth defect risk
  • 批准号：
    10602447
  • 项目类别：
  • 资助金额：
    $40.7万
  • 财政年份：
    2022
  • 负责人：
    Mary L. Marazita
  • 依托单位：
    JOHNS HOPKINS UNIVERSITY
Differences between the sexes among genetic variants affecting orofacial cleft birth defect risk
  • 批准号：
    10420286
  • 项目类别：
  • 资助金额：
    $41.55万
  • 财政年份：
    2022
  • 负责人：
    Mary L. Marazita
  • 依托单位：
    JOHNS HOPKINS UNIVERSITY
Enhanced Data from Orofacial Cleft Trios to Strengthen the Gabriella Miller Kids First (GMKF) Discovery Goals
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