Association Study of Orofacial Cleft Risk Variants across All of Us Cancer Diagnoses

所有癌症诊断中口面裂风险变异的关联研究

• 批准号: 10654330
• 负责人: Mary L. Marazita
• 金额: $ 11.81万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10654330
• 关键词: Address; Administrative Supplement; Behavior Therapy; Child; Cleft Lip; Data; Data Set; Dental; Face; Genes; Genetic; Genetic Risk; Goals; Grant; Human; Individual; Infant Mortality; Intervention; Life; Live Birth; Malignant Neoplasms; Medical; Nutritional; Operative Surgical Procedures; Palate; Public Health; Risk Factors; Speech; Structural Congenital Anomalies; Treatment Cost; Variant; cancer diagnosis; cancer risk; comorbidity; data harmonization; feeding; genetic architecture; health economics; high risk; mortality; orofacial cleft; parent grant; risk variant

ABSTRACT This new grant is a Revision/Administrative Supplement to parent grant R03-DE032062. It has long been noted that individuals with orofacial clefts (OFCs) and their unaffected relatives have a higher risk of certain cancers. The hypothesis of this revision is that the association between OFC and cancer is in part due to genetic commonalities. In this Revision, we will investigate possible associations between OFC genetic risk variants with the cancer diagnoses in All of Us.

摘要 这项新的补助金是对父补助金R03-DE032062的修订/行政补充。很早以前就有人注意到 患有口面部裂(OFCs)的人及其未受影响的亲属患某些疾病的风险较高 癌症。这项修订的假设是OFC与癌症之间的联系部分是由于 遗传上的共性。在这次修订中，我们将调查OFC遗传风险之间可能的关联 变种与我们所有人的癌症诊断。