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System construction of calculating the patient doses and its related cancer risk from CT examination in Japan

日本CT检查计算患者剂量及其相关癌症风险的系统构建

基本信息

批准号：
18591363
负责人：
KAI Michiaki
金额：
$ 2.41万
依托单位：
Oita University of Nursing and Health Sciences
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591363/
关键词：
CT examination organ dose radation-related cancer risk estimate medical exposure 発がんリスク臓器線量シングルCT マルチスライスCT CT X線

项目摘要

We carried out a nation-wide survey to estimate the yearly frequency of CT examinations. As a result, the frequency of CT examinations was strongly correlated with the number of beds in hospital. When calculation was made using the number of beds in each hospital that has CT equipment, the yearly CT frequency of 2005 in Japan was estimated to be about 27 million. The frequency of pediatric CT examinations under 16 years old can be estimated using the proportion of age-dependent frequency and then resulted in about 78,000. The organ dose from each CT examination must be estimated based on the exposure condition and exposed region. We took calculation-based approach using available programs such as ImPACT and CT-EXPO, because it is impossible to measure the dose from each CT examination in hospital. The calculated data were validated by the measured data and then some organ doses showed 20% higher than measured. There are some controversies about current estimates of radiation-related cancer risk in low dose and dose rates using LNT models. However, the dose from CT examinations is about 10 mGy and it remains unclear whether several ten mGy would give a significant higher excess cancer risk to children exposed on medical purposes. To investigate the health effects of CT uses, we constructed a system of calculating cancer risk related with CT frequency and doses obtained by our results. To establish a follow-up cohort of children exposed to CT, this system would be useful for possible interpretation based on actual data such as doses and CT frequency.

我们进行了一项全国范围的调查，以估算每年 CT 检查的频率。因此，CT检查的频率与医院床位数量密切相关。根据各医院拥有CT设备的床位数计算，日本2005年每年的CT检查次数约为2700万次。 16岁以下儿童CT检查频次可以通过年龄相关频次比例估算得出，约为78,000例。每次CT检查的器官剂量必须根据暴露条件和暴露区域来估计。我们采用基于计算的方法，使用 ImPACT 和 CT-EXPO 等可用程序，因为不可能测量医院每次 CT 检查的剂量。计算数据经测量数据验证，部分器官剂量显示比测量数据高出 20%。目前使用 LNT 模型对低剂量和剂量率下与辐射相关的癌症风险的估计存在一些争议。然而，CT 检查的剂量约为 10 mGy，尚不清楚数十 mGy 是否会给出于医疗目的暴露的儿童带来显着更高的额外癌症风险。为了研究 CT 使用对健康的影响，我们构建了一个计算与 CT 频率和根据我们的结果获得的剂量相关的癌症风险的系统。为了建立接受 CT 治疗的儿童的随访队列，该系统将有助于根据剂量和 CT 频率等实际数据进行可能的解释。