Project 1: Deployable Software for the Rapid Assessment of Organ Dose Following Radionuclide Intakes

项目 1:用于快速评估放射性核素摄入后器官剂量的可部署软件

基本信息

  • 批准号:
    10589871
  • 负责人:
  • 金额:
    $ 39.27万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-03-10 至 2027-02-28
  • 项目状态:
    未结题

项目摘要

PROJECT 1: ABSTRACT This project will develop field-deployable software which, together with external detector measurements, will permit triage-level reporting of organ dose to individuals internally contaminated with radionuclides following Radiological Dispersion Device (RDD), Improvised Nuclear Device (IND), or Nuclear Reactor Accident (NRA) release. These dose estimates will help drive decisions on medical countermeasures and support other forms of exposure assessment such as injury biomarkers. While existing radiological triage software are based on a single pair of 50th percentile adults and a limited array of RDD radionuclides, our software will permit triage screening across a realistic population of adults of varying heights and weights, expansion of this data to include size- variable children and pregnant females, and expansion of the radionuclides considered to include time- dependent fission product mixtures. Our first hypothesis is that a revised series of human anatomic phantoms with detailed models of intra-organ vasculature will permit accurate accounting for circulating blood as an independent source region (important for shorter-lived radionuclides) and will permit realistic estimates of dose to organ parenchyma (important for short-ranged radiations). While these macroscale estimates of organ parenchyma dose are sufficient for in-field radiological triage, this project will additionally perform refined tissue dosimetry as needed for dose-response modeling of organ toxicity. Our second hypothesis is that radionuclide activity is unevenly distributed at the mesoscale (tissue) and microscale (cellular) levels, and thus for short- ranged alpha and beta radiations, there exists a distribution of dose to cell populations to include stem cells, functional subunits, and immunological cells. We will address these hypotheses with the following aims. Aim 1: Model organ-level vasculature within a morphometrically diverse library of computational humans to include adults, children, and pregnant females. Aim 2: Compute radionuclide S values and evaluate detector responses across the entire Aim 1 phantom library. Aim 3: Use the detector responses from Aim 2 and the biokinetic data from Project 2 to design and construct GECAT (the Gamma-Emitter Contamination Assessment Tool). Aim 4: Expand GECAT to include needed radiological triage data for a whole-body scanner designed and validated within Project 2. Aim 5: Develop mesoscale (tissue) and microscale (cell) level mesh-based histology models of the lungs, liver, spleen, and bone marrow, which when coupled to x-ray fluorescent microscopy data from Project 3 (using archived tissues from canine studies of radionuclide inhalation and tissue deposition), will allow us to compute dose distributions to cellular populations that drive radionuclide-induced organ toxicities. This work will be further expanded using XFM data in murine studies of radionuclide inhalation with both pre-exposure and post-exposure administration of a new generation of radionuclide decorporation agents.
项目一:摘要

项目成果

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WESLEY E BOLCH其他文献

WESLEY E BOLCH的其他文献

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{{ truncateString('WESLEY E BOLCH', 18)}}的其他基金

Microscale Radionuclide S-values for αRPT
αRPT 的微量放射性核素 S 值
  • 批准号:
    10713711
  • 财政年份:
    2023
  • 资助金额:
    $ 39.27万
  • 项目类别:
Project 1: Deployable Software for the Rapid Assessment of Organ Dose Following Radionuclide Intakes
项目 1:用于快速评估放射性核素摄入后器官剂量的可部署软件
  • 批准号:
    10327396
  • 财政年份:
    2022
  • 资助金额:
    $ 39.27万
  • 项目类别:
Developing whole-body computational phantoms for blood dosimetry to model the impact of radiation on the immune system
开发用于血液剂量测定的全身计算模型,以模拟辐射对免疫系统的影响
  • 批准号:
    10429988
  • 财政年份:
    2020
  • 资助金额:
    $ 39.27万
  • 项目类别:
Developing whole-body computational phantoms for blood dosimetry to model the impact of radiation on the immune system
开发用于血液剂量测定的全身计算模型,以模拟辐射对免疫系统的影响
  • 批准号:
    10655343
  • 财政年份:
    2020
  • 资助金额:
    $ 39.27万
  • 项目类别:
Developing whole-body computational phantoms for blood dosimetry to model the impact of radiation on the immune system
开发用于血液剂量测定的全身计算模型,以模拟辐射对免疫系统的影响
  • 批准号:
    10214573
  • 财政年份:
    2020
  • 资助金额:
    $ 39.27万
  • 项目类别:
MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid Imaging
MIRDCalc — 用于导出和报告核医学、计算机断层扫描和混合成像中患者器官剂量的社区工具
  • 批准号:
    10200807
  • 财政年份:
    2019
  • 资助金额:
    $ 39.27万
  • 项目类别:
MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid Imaging
MIRDCalc — 用于导出和报告核医学、计算机断层扫描和混合成像中患者器官剂量的社区工具
  • 批准号:
    10456116
  • 财政年份:
    2019
  • 资助金额:
    $ 39.27万
  • 项目类别:
MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid Imaging
MIRDCalc — 用于导出和报告核医学、计算机断层扫描和混合成像中患者器官剂量的社区工具
  • 批准号:
    10696129
  • 财政年份:
    2019
  • 资助金额:
    $ 39.27万
  • 项目类别:
MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid Imaging
MIRDCalc — 用于导出和报告核医学、计算机断层扫描和混合成像中患者器官剂量的社区工具
  • 批准号:
    10017971
  • 财政年份:
    2019
  • 资助金额:
    $ 39.27万
  • 项目类别:
APPLICATION OF MR IMAGING TO THE STUDY OF BONE DOSIMETRY
MR成像在骨剂量研究中的应用
  • 批准号:
    7182973
  • 财政年份:
    2005
  • 资助金额:
    $ 39.27万
  • 项目类别:

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