癌の腹膜播種原因遺伝子の同定と新しい分子標的治療

癌症腹膜播散基因的鉴定和新的分子靶向治疗

基本信息

批准号：
18591495
负责人：
KAWAMURA Taiichi
金额：
$ 2.4万
依托单位：
Shizuoka Cancer Center
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

Origin of peritoneal carcinomatsis is considered from peritoneal free cancer cells exfoliated from serosal surface of the primary tumor or spilled from the blood vessels/lymphatic vessels during the surgical dissection. These peritoneal free cancer cells have high proliferative activity of greater than 50% of Ki67-labeling rate, measured by MIB-1 monoclonal antibody. Accordingly, peritoneal free cancer cells start to proliferate immediately if they attach on the peritoneal surface. By the scanning electromicroscopy, some kinds of cytokines induce morphological changes of peritoneal mesothelial cells. EGF, IL-6 and hGF induce contraction of peritoneal mesothelial cells, and then submesothelial basement membrane and the orifice of submesthelial lymphatic vessels are exposed.A new cascade of peritoneal metastasis, called as trans-lymphatic metastasis is studied. The lymphatics and blood vessels in the human peritoneum with peritoneal carcinomatosis were studied using by the method of 5'-N … More ase-ALPase and D2-40 immunostatining. Cancer cells are found in the submesothelial lymphatic vessels in the milky spots, diaphragmatic lymphatics and the initial lymphatics in the pelvis and Morrison pouch. In the milky spots, many arterial blood capillaries distribute around the lymphatic sinus. Dilatation and newly formed lymphatic vessels were found, and are classified into four patterns, like budding, ladder formation, etension and island formation. High levels of VEGF-C and VEGF-A were detected in the ascites. VEGF-C has a role in the formation of lymphangiogenesis.From these results, peritoneal free cancer cells migrate into the submesothelial lymphatic vessels. Accordingly, trans-lymphatic metastasis is an important metastatic process on the formation of peritoneal dissemination, and VEGF-C has a big role in the neoformation of submesothelial lymphatic vessels.A new surgical method called peritonectomy is the surgical procedure to remove peritoneal zones with well developed lymphatic networks, and enables to perform complete removal of PC. Furthermore, intraperitoneal chemotherapy effectively kills cancer cells in the submesothelial lymphatics by making a high locoregional concentrations of anticancer drugs. Less

腹膜致癌的起源是从从原发性肿瘤的血清表面去除的腹膜无癌细胞或手术扫描过程中从血管/淋巴管中溢出的。这些无腹膜癌细胞具有高于MIB-1单克隆抗体测量的Ki67标记率的50％的高增殖活性。彼此之间，如果腹膜癌细胞附着在腹膜表面上，它们就会立即增殖。通过扫描电显微镜检查，某些细胞因子诱导腹膜间皮细胞的形态变化。 EGF，IL-6和HGF诱导腹膜间皮细胞的收缩，然后暴露于腹膜淋巴病视频的孔口和腹膜淋巴病视频的孔口。一种新的腹膜转移疗法，称为跨乳液转移。使用5'-N的方法研究了人腹膜中腹膜中腹膜中的淋巴细胞和血管。癌细胞在乳状斑点，diaphragmatoratic淋巴管和骨盆和莫里森小袋中的初始淋巴管中发现。在乳状斑点中，许多动脉血毛细血管分布在淋巴窦周围。发现扩张和新形成的淋巴管，并被分类为四种模式，例如萌芽，梯子形成，依恋和岛屿形成。在腹水中检测到高水平的VEGF-C和VEGF-A。 VEGF-C在淋巴管生成的形成中起作用。从这些结果，腹膜无癌细胞迁移到子皮淋巴管中。据此，跨淋巴转移是形成腹膜传播的重要转移过程，而VEGF-C在腹膜淋巴管的新形态中具有很大的作用。一种称为腹膜腹膜术的新型手术方法，称为腹膜纵切除术是为了删除具有良好发达的网络的外科手术程序，可连接良好的淋巴结，并能够完成淋巴结良好的效果。此外，腹膜内化学疗法通过使高局部抗癌药物的较高浓度的抗癌药物有效地杀死癌细胞。较少的

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A systemic review and meta-analysis of the randomized controlled trails on adjyuvant intraperitoneal chemotherapy for respectable gastric cancer.

对胃癌辅助腹腔化疗随机对照试验的系统回顾和荟萃分析。

DOI：
发表时间：
2007
期刊：
Ann Surg Oncol. 14
影响因子：
0
作者：
1. Yan TD;Black D;Sugarbaker PH;Zhu J;Yonemura Y;Petrou G;Morris DL.2007 :
通讯作者：
Morris DL.2007 :

「研究成果報告書概要(和文)」より

摘自《研究结果报告摘要（日文）》

DOI：
发表时间：
2005
期刊：
影响因子：
0
作者：
Kawauchi;et. al.;Nishimura et al.;Dezawa et al.;Yoshizawa et al.;星野幹雄;星野幹雄
通讯作者：
星野幹雄

Recent advances in the treatment of peritoneal dissemination of gastroinstinal cancers by nucleoside antimetabolites.,, 2007

核苷抗代谢物治疗胃肠癌腹膜播散的最新进展，，2007

DOI：
发表时间：
2007
期刊：
Cancer Sci. 98
影响因子：
0
作者：
Naoto Miyagawa;Koji Kono;Kousaku Mimura;Hideo Omata;Hidemitsu Sugai;Hideki Fujii.;Yutaka Yonemura;Yutaka Yonemura;Yonemura Y
通讯作者：
Yonemura Y

Quantitative prognostic indicators of peritoneal dissemination of gastric cancer