Molecular Genetic Analysis of Genes Regulating Metabolism in the Fungus Aspergillus nidulans

构巢曲霉代谢调节基因的分子遗传学分析

• 批准号: DP0345268
• 负责人: Prof Michael Hynes
• 金额: $ 95.12万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0345268
• 关键词: Molecular; Genetic; Analysis; Genes; Regulating

Filamentous fungi can use a wide variety of sources of carbon and nitrogen. In order to grow on these compounds metabolism is adjusted in response to changes in nutrient availability. Patterns of genome expression are altered by signalling to global regulatory genes which control the transcription of genes producing enzymes appropriate to the substrates available. This is of fundamental significance to the physiology and development of fungi which include devastating pathogens and species used in industrial microbiology. This project aims to use the excellent molecular genetics of the model fungus Aspergillus nidulans to investigate the strategies employed and the mechanisms involved.

丝状真菌可以利用各种各样的碳源和氮源。为了在这些化合物上生长，代谢响应于营养物质可用性的变化而进行调整。基因组表达模式通过向全局调节基因发出信号而改变，全局调节基因控制基因的转录，产生适合于可用底物的酶。这对真菌的生理学和发育具有重要意义，其中包括工业微生物学中使用的毁灭性病原体和物种。本项目旨在利用模式真菌构巢曲霉的优良分子遗传学来研究所采用的策略和所涉及的机制。