Global genetic regulation of carbon metabolism in filamentous fungi.

丝状真菌碳代谢的全球遗传调控。

• 批准号: DP0987461
• 负责人: Prof Michael Hynes
• 金额: $ 23.9万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0987461
• 关键词: Global; genetic; regulation; carbon; metabolism

Fungi are of great importance in medicine, agriculture and industry. They are used extensively for food, antibiotic and chemical production and, increasingly, for generating cheap substrates for bioethanol. However many are serious pathogens of plants and humans. Understanding how fungi control their metabolism is of fundamental importance for their more effective use or control. This project takes advantage of a fungus that is easily studied in the laboratory by advanced genetic techniques to identify the ways in which genes are turned on and off in response to changes in the nutrients available. By comparing DNA sequences the results are readily applied to fungi of economic importance.

真菌在医药、农业和工业中都很重要。它们广泛用于食品、抗生素和化学品生产，并越来越多地用于生产廉价的生物乙醇底物。然而，许多是植物和人类的严重病原体。了解真菌如何控制它们的代谢对于它们更有效地利用或控制是至关重要的。该项目利用了一种真菌，这种真菌很容易在实验室中通过先进的遗传技术进行研究，以确定基因在应对可用营养物质变化时开启和关闭的方式。通过比较DNA序列，结果很容易应用于具有经济意义的真菌。