A study of target recognition and axon branching m hanisms in the thalamomrocalpmjection
丘脑注射中目标识别和轴突分支机制的研究
基本信息
- 批准号:18300105
- 负责人:
- 金额:$ 10.75万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2006
- 资助国家:日本
- 起止时间:2006 至 2007
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The thalamocortical (TC) projection in the mammalian brain is a well characterized system in terms of laminar specificity of neocortical circuits. To understand the mechanisms that underlie lamina-specific TC axon targeting, the role of extracellular and cell surface molecules which are expressed in the upper layers of the developing cortex was studied in vitro culture techniques. The result demonstrated that multiple upper layer molecules cooperated to produce stop behavior of TC axons in the target layer. Activity dependency of TC axon branching was also investigated in organotypic cocultures of the thalamus and cortex. TC axon branches were formed dynamically by addition and elimination during the second week in vitro, when spontaneous firing increased in thalamic and cortical cells. Pharmacological blockade of firing or synaptic activity reduced the remodeling process, in particular, branch addition in the target layer. Together, these findings suggest that TC axon targeting mechanisms involve the regulation with multiple lamina-specific molecules and modification of the molecular mechanisms via neural activity.
哺乳动物大脑中的丘脑皮质(TC)投射是一个具有新皮质环路板层特异性的系统。为了了解板层特异性TC轴突靶向的机制,在体外培养技术中研究了在发育中的皮质上层表达的细胞外和细胞表面分子的作用。结果表明,多个上层分子协同作用产生了靶层TC轴突的停止行为。在丘脑和皮质的器官型共培养中,还研究了TC轴突分支的活动依赖性。在体外培养的第二周,丘脑和皮质细胞自发放电增多时,TC轴突分支通过添加和消除动态形成。对放电或突触活动的药物阻断减少了重塑过程,特别是靶层中分支的增加。综上所述,这些发现表明,TC轴突靶向机制涉及多个板层特异性分子的调节和通过神经活动对分子机制的修改。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Activity-independent and dependent mechanisms for the formation of the thalamocortical projection
丘脑皮质投射形成的活动独立和依赖性机制
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Yamamoto;N.;Uesaka;N.;Hayano;Y.;Yamada;A
- 通讯作者:A
Cooperative activity of multiple upper layer proteins for thalamocortical axon growth
- DOI:10.1002/dneu.20592
- 发表时间:2008-02-15
- 期刊:
- 影响因子:3
- 作者:Maruyama, Takuro;Matsuura, Masahiro;Yamamoto, Nobuhiko
- 通讯作者:Yamamoto, Nobuhiko
Activity-dependent regulation of cortical axon branching
皮质轴突分支的活动依赖性调节
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:Uesaka N.;Yamamoto N
- 通讯作者:Yamamoto N
大脳皮質神経細胞におけるHDAC9の神経活動依存的な核・細胞質間移動による遺伝子発現と樹状突起形成の制御
大脑皮层神经元中 HDAC9 神经元活动依赖性核细胞质运动对基因表达和树突形成的调节
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Sugo;N・Oshiro;H・Song;W・Yamamoto;N
- 通讯作者:N
「研究成果報告書概要(和文)」より
摘自《研究结果报告摘要(日文)》
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:Kawauchi;et. al.;Nishimura et al.;Dezawa et al.;Yoshizawa et al.;星野 幹雄;星野 幹雄
- 通讯作者:星野 幹雄
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YAMAMOTO Nobuhiko其他文献
YAMAMOTO Nobuhiko的其他文献
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{{ truncateString('YAMAMOTO Nobuhiko', 18)}}的其他基金
Cytoskeleton mechanisms of activity-dependent axon branching
活动依赖性轴突分支的细胞骨架机制
- 批准号:
15H04260 - 财政年份:2015
- 资助金额:
$ 10.75万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
A study of human neuronal circuit formation using iPS cells
使用 iPS 细胞研究人类神经回路形成
- 批准号:
15K14318 - 财政年份:2015
- 资助金额:
$ 10.75万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Dynamics of thalamocortical axon growth and branching in the developing visual cortex
发育中的视觉皮层丘脑皮质轴突生长和分支的动态
- 批准号:
23650207 - 财政年份:2011
- 资助金额:
$ 10.75万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
The Mechanism Underlying the Formation of Activity-Dependent Thalamocortical Projection
活动依赖性丘脑皮质投射形成的机制
- 批准号:
20300110 - 财政年份:2008
- 资助金额:
$ 10.75万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Molecular mechanisms of lamina-specific neural circuit formation in the neocortex
新皮质层层特异性神经回路形成的分子机制
- 批准号:
15300107 - 财政年份:2003
- 资助金额:
$ 10.75万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
A study of the membrane-bound factors that underlie the formation of thalamocortical projections
丘脑皮质投射形成背后的膜结合因子的研究
- 批准号:
13680870 - 财政年份:2001
- 资助金额:
$ 10.75万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Activity-dependent circuit formation in the neocortex
新皮质中活动依赖性回路的形成
- 批准号:
11680788 - 财政年份:1999
- 资助金额:
$ 10.75万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A study of mechanisms for formation of thalamocortical projectic
丘脑皮质投射形成机制的研究
- 批准号:
09680793 - 财政年份:1997
- 资助金额:
$ 10.75万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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