Development of Materials for Asymmetric Recognition by Chiral Modification of Ordered Mesoporous Materials

通过有序介孔材料的手性修饰开发用于不对称识别的材料

• 批准号: 18360387
• 负责人: KUBOTA Yoshihiro
• 金额: $ 11.28万
• 依托单位: Yokohama National University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18360387/
• 关键词: ordered porous material; mesoporous silica; material for asymmetric recognition; catalyst; adsorbent; surfactant; self-organization; helical pore

Mesoporous silica AMS (anionic surfactant templated mesoporous silica) with helical particles were successfully synthesized by using the chiral anionic surfactants N-miristoyl derivatives of D- and L-alanines (C_<14>-L-AlaA and C_<14>-D-AlaA), as well as D- and L-valines (C_<14>-L-ValA and C_<14>-D-ValA). The left-/right-handed ratios for the helical particles synthesized with L-isomers and D-isomers proved to be 75/25 and 25/75, respectively, suggesting that the predominant handedness of helices was directed by the handedness of the surfactants. The synthesis conditions for obtaining a chiral mesoporous silica have been optimized. The macroscopic morphology as well as the mesostructure of the chiral mesoporous silica was extremely sensitive to the synthetic conditions. The influence of the stereoisomerism of the chiral surfactant on the mesostructure and morphology of chiral AMS was investigated by using a mixture of C_<14>-L-AlaA and C_<14>-D-AlaA. Helical rod-shaped AMS was found to be effective for asymmetric separation of recemic trifluoroacetylalanine ethyl ester (CF_3CO-Ala-Oet). Synthesis of AMS by using asparagin derivatives has also been investigated.

采用手性阴离子表面活性剂n -咪唑醇衍生物（c <14>- l - alaa和c <14>-D- alaa）和D-缬氨酸（c <14>- l - vala和c <14>-D- vala），成功合成了带有螺旋颗粒的介孔二氧化硅（阴离子表面活性剂模板化介孔二氧化硅）。由l -异构体和d -异构体合成的螺旋粒子的左/右旋比分别为75/25和25/75，表明螺旋的优势旋向性是由表面活性剂的旋向性决定的。优化了手性介孔二氧化硅的合成条件。手性介孔二氧化硅的宏观形貌和介孔结构对合成条件非常敏感。用C_<14>-L-AlaA和C_<14>-D-AlaA的混合物研究了手性表面活性剂的立体异构性对手性AMS介观结构和形貌的影响。螺旋棒状AMS可有效地分离近消旋三氟乙酰丙氨酸乙酯（CF_3CO-Ala-Oet）。还研究了利用天冬酰胺衍生物合成AMS的方法。

项目成果

Periodic arrangement of silica nanospheres assisted by amino acids

• DOI: 10.1021/ja065071y
• 发表时间: 2006-10-25
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Yokoi, Toshiyuki;Sakamoto, Yasuhiro;Tatsumi, Takashi
• 通讯作者: Tatsumi, Takashi

Al-MWW層状前駆体の層間シリル化による新規大孔径ゼオライト触媒の調製 (注目発表)

通过 Al-MWW 层状前驱体的层间硅烷化制备新型大孔沸石催化剂（著名演讲）

• 发表时间: 2007
• 作者: T.Yokoi;Y.Sakamoto;O.Terasaki;Y.Kubota;T.Okubo;T.Tatsumi;辰巳 敬;窪田好浩;辰巳 敬;辰巳 敬
• 通讯作者: 辰巳 敬

Nanostructural modification of organic-tethered MCM-22 catalyst

有机束缚MCM-22催化剂的纳米结构修饰

• 发表时间: 2007
• 作者: W;Fan;S;Wei;T;Yokoi;P;Wu;Y;Kubota;T;Tatasumi;Yoshihiro Kubota
• 通讯作者: Yoshihiro Kubota

多次元細孔チタノシリケートTi-MCM-68の合成と触媒性能

多维孔钛硅酸盐Ti-MCM-68的合成及催化性能

• 发表时间: 2007
• 作者: Y;Kubota;M;Yoshida;T;Tatsumi;辰巳 敬;窪田好浩;窪田好浩
• 通讯作者: 窪田好浩

水蒸気処理によるCHA型ゼオライトの脱アルミニウム

CHA型沸石的蒸汽处理脱铝

• 发表时间: 2007
• 作者: Y;Kubota;M;Yoshida;T;Tatsumi;辰巳 敬;窪田好浩;窪田好浩;辰巳 敬;辰巳 敬
• 通讯作者: 辰巳 敬