Molecular biological analysis by organ culture and application to fetal treatment using mice model with anorectal malformation

器官培养的分子生物学分析及其在肛门直肠畸形小鼠模型胎儿治疗中的应用

• 批准号: 21592276
• 负责人: KUBOTA Yoshihiro
• 金额: $ 3万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592276/
• 关键词: 直腸肛門奇形; 器官培養; 胎仔治療

A single high dose of etretinate, a long-acting synthetic retinoid, induces ARMs in mice. Abnormal intrinsic innervation of mice embryos with anorectal malformations at later developmental stages was eliminated by molecular biological methods. Organ culture was quite difficult, but it will be possible to succeed it. It is necessary to continue to study it.

一种长效的合成视黄酸，一次高剂量的etretate，就能在小鼠身上诱导手臂。用分子生物学方法消除了发育后期小鼠肛门直肠畸形胚胎的异常固有神经支配。器官培养相当困难，但它是有可能成功的。有必要继续研究。

项目成果

Abnormal development of intrinsic innervation of murine embryos with anorectal malformation

肛门直肠畸形小鼠胚胎内在神经支配发育异常

• 发表时间: 2010
• 作者: Kodaka T;Ohta S;Kanamori Y;et al;Kubota Y.
• 通讯作者: Kubota Y.

Abnormal development of intrinsic innervation in murine embryos with anorectal malformations

肛门直肠畸形小鼠胚胎内在神经支配发育异常

• 发表时间: 2012
• 期刊: Pediatric Surgery International
• 影响因子: 1.8
• 作者: Kubota Y;Cho H;Umeda T;Abe H;Kurumi Y;Tani T.
• 通讯作者: Tani T.

Abnormal development of intrinsic innervation of marine embryos with anorectal malformation

肛门直肠畸形海洋胚胎内在神经支配发育异常

• 发表时间: 2010
• 作者: Kodaka T;Ohta S;Kanamori Y;et al;Yoshihiro Kubota
• 通讯作者: Yoshihiro Kubota