Survey on human contamination by brominated flame retardants and chlorinated/brominated dioxins for the health risk factor of mother and child

溴化阻燃剂和氯化/溴化二恶英对人体的污染及母婴健康危险因素调查

基本信息

批准号：
18390202
负责人：
OHTA Souichi
金额：
$ 4.67万
依托单位：
Setsunan University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

In order to clear human exposure by Co-PXBs, it was investigated the Co-PXBs concentration in the breast milk (sampling day; 5 and 30 days) of Japanese multiparae and primiparae. The concentration of Co-PXBs ranged between 0.42 and 1.41 pg TEQ/g lipid, and this observation is our first finding for human exposure by Co-PXBs. With respect the average TEQ level in mother's milk, there is no difference between of multiparae and primiparae, not in the case of CO-PCBs. Interestingly, when the level of Co-PCBs at 5 and 30 days of same woman was compared, that at 5 days-breast milk samples were higher than that at 30days-samples for almost sample analyzed. However, in the case of CO-PXBs, such tendency was not always observed.Then, the abundant congeners of Co-PXBs were #126A, #126 B and #169, and it was estimated that human exposure by this Co-PXBs #126B is derived from the eating of fish. Then, it was compared the contribution ratio of four kinds of dioxin analogues for total TEQ concentration in mother's milk of Japan. Major analogues were PCDDs/DFs, Co-PCBs and Co-PXBs, and PXDDs/DFs were negligible level, showing unexpected high contribution ratio of Co-PXBs in the breast milk of multiparae. As there are theoretically more few hundreds congeners in the Co-PXBs group, and therefore it needs further detail survey of Co-PXBs contaminationFurther study is warranted to evaluate whether Co-PXBs exposures to nursing infants pose a health risk. Additional investigations of Co-PXBss in the daily foods are warranted to better understand the nature and extent of Co-PXBs contamination of Japanese food supply.

为了清除co-PXB的人类暴露，对日本多毛和primiparae的母乳（采样日； 5和30天）中的co-PXBS浓度进行了研究。 Co-PXB的浓度在0.42至1.41 pg TEQ/G脂质之间，这一观察结果是我们对人类co-PXBS暴露的第一个发现。就母乳中的平均TEQ水平而言，多毛和乳脂病之间没有差异，而不是co-pcbs。有趣的是，当比较同一妇女的5和30天的co-pbs水平时，在5天的乳房样本中，牛奶样本高于30天样本，几乎分析了样本。但是，在Co-PXB的情况下，并不总是观察到这种趋势。然后，co-PxB的丰富同源物为＃126A，＃126 B和＃169，据估计，该Co-PXBS＃126B的人类暴露于鱼类的食用中。然后，比较了日本母牛奶中TEQ浓度的四种二恶英类似物的贡献比。主要类似物是PCDDS/DFS，Co-PCB和Co-PXB，PXDDS/DFS的水平可以忽略不计，显示出意外的高贡献率在多拉（Multiparae）的母乳中。由于理论上有更多的Co-PXBS组，因此需要对Co-PXBS污染的进一步详细调查，以评估CO-PXBS对疗养婴儿的暴露是否构成健康风险。需要对每日食品中的co-PXBS进行进一步的调查，以更好地了解日本食品供应的co-PXBS污染的性质和程度。