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Survey on human contamination by brominated flame retardants and chlorinated/brominated dioxins for the health risk factor of mother and child

溴化阻燃剂和氯化/溴化二恶英对人体的污染及母婴健康危险因素调查

基本信息

批准号：
18390202
负责人：
OHTA Souichi
金额：
$ 4.67万
依托单位：
Setsunan University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

In order to clear human exposure by Co-PXBs, it was investigated the Co-PXBs concentration in the breast milk (sampling day; 5 and 30 days) of Japanese multiparae and primiparae. The concentration of Co-PXBs ranged between 0.42 and 1.41 pg TEQ/g lipid, and this observation is our first finding for human exposure by Co-PXBs. With respect the average TEQ level in mother's milk, there is no difference between of multiparae and primiparae, not in the case of CO-PCBs. Interestingly, when the level of Co-PCBs at 5 and 30 days of same woman was compared, that at 5 days-breast milk samples were higher than that at 30days-samples for almost sample analyzed. However, in the case of CO-PXBs, such tendency was not always observed.Then, the abundant congeners of Co-PXBs were #126A, #126 B and #169, and it was estimated that human exposure by this Co-PXBs #126B is derived from the eating of fish. Then, it was compared the contribution ratio of four kinds of dioxin analogues for total TEQ concentration in mother's milk of Japan. Major analogues were PCDDs/DFs, Co-PCBs and Co-PXBs, and PXDDs/DFs were negligible level, showing unexpected high contribution ratio of Co-PXBs in the breast milk of multiparae. As there are theoretically more few hundreds congeners in the Co-PXBs group, and therefore it needs further detail survey of Co-PXBs contaminationFurther study is warranted to evaluate whether Co-PXBs exposures to nursing infants pose a health risk. Additional investigations of Co-PXBss in the daily foods are warranted to better understand the nature and extent of Co-PXBs contamination of Japanese food supply.

为清除Co-PXbs对人体的暴露，调查了日本经产妇和初产妇母乳中Co-PXbs的浓度。Co-PXbs的浓度在0.42至1.41 pg TEQ/g脂肪之间，这是我们首次发现人体接触Co-PXbs。关于母乳中的平均TEQ水平，经产妇和初产妇之间没有差别，CO-PCB的情况除外。有趣的是，当比较同一妇女出生第5天和第30天的Co-PCbs水平时，第5天的母乳样本高于第30天的样本，几乎所有样本都被分析了。然而，在CO-PXB的情况下，并不总是观察到这种趋势。然后，Co-PXB的丰富同系物是#126A、#126B和#169，据估计，人类接触这种Co-PXBS#126B来自于吃鱼。比较了四种二恶英类似物对日本母乳中总TEQ浓度的贡献率。主要类似物为PCDDs/DFS、Co-PCbs和Co-PXbs，PXDDs/DFS的含量可以忽略不计，显示Co-PXbs在多胎母乳中的贡献率出人意料地高。由于理论上Co-PXbs组中有数百个同系物，因此需要对Co-PXbs的污染进行进一步的详细调查。有必要进行进一步的研究，以评估Co-PXbs接触哺乳婴儿是否构成健康风险。有必要对日常食品中的Co-PXBss进行更多的调查，以更好地了解日本食品中Co-PXbs污染的性质和程度。