Elucidation of Environmental and human body burden by Brominated Flame Retordants in Japan

目前，对日本环境和人体中多溴联苯醚（PBDEs）、四溴双酚A（TBBPA）和三溴苯酚（2，4，6-TBP）的污染状况还知之甚少。在1988年和1989年的样品中观察到显著的污染，显示超过400纳克/克脂肪碱。但从1990年开始，这种蓄积水平逐渐下降，1999年样品中蓄积水平降至5%左右，与1989年的最高水平相比，这一趋势在大和河鼠口采集的乌鱼样品中也有类似的趋势。1987年和1999年对鲻鱼的比较研究也发现了类似的现象，因此，六溴二苯醚同系物的异构体比例随着时间的变化而相对增加。上述意见得到支持， ...更多信息 1990年，五溴二苯醚同系物被禁止用于工业材料，日本的十溴二苯醚消费量也逐年下降（数据未显示）。接下来，还测定了12名产妇分娩后一个月母乳中的多溴二苯醚浓度，以确定饮食中的多溴二苯醚浓度与人体中的多溴二苯醚浓度之间的关系。母乳中的多溴联苯醚浓度在668至2，840皮克/克脂肪之间，与瑞典和其他地方报告的哺乳妇女人群中的浓度相当。母乳中的多溴二苯醚浓度与鱼类和贝类的饮食摄入量之间存在很强的正相关关系，这一点在妇女对食物消费习惯问卷的答复中得到了证实。这项针对日本普通消费食品的研究结果以及在哺乳期妇女中发现的多溴二苯醚含量，引起了人们对鱼类和其他供人类消费的食品受到低水平多溴二苯醚污染的关注。此外，在奶粉中也观察到奶粉中多溴联苯醚浓度较高。少

At present, little is known about the occurrence of polybrominated diphenyl ethers(PBDEs), tetrabromobisphenol A(TBBPA) and Tribromophenole(2,4,6-TBP) in the environment and human of Japan, First, the time-dependent alteration of PBDEs contamination observed in the long-term stock-fish samples(Japanese sea bass ; 1986-1999) from Osaka Bay was investigated. A remarkable pollution was observed in the samples of 1988 and 1989, showing over 400 ng/g fat bases. However, It was found that such accumulation levels gradually decreased from 1990, and the accumulation level in the sample of 1999 reduced to about 5%, comparing with that of 1989 as the maximum level, Similar tendency was also observed in the samples of Grey mullet, collected at the mouse of Yamato River. Similar phenomenon was also recognized by the comparative studies of grey mullet of 1987 and 1999, Thus, the isomer ratios of HxBDE congeners were relatively increased with time alteration. The above observation was supported that … More PeBDEs congener prohibited applying for the industrial materials in 1990, and DeBDE consumption also decreased year after year in Japan(data not shown). Next, the concentrations of PBDEs in the breast milk of 12 primiparae nursing women at one month after delivery also were determined to ascertain the relationship between the levels found in the diet and levels in humans. In human milk, ΣPBDE concentrations ranged between 668 and 2,840 pg/g lipid basis, which is comparable to the levels in populations of nursing women reported in Sweden and elsewhere. There was a strong positive relationship between-PBDE concentrations in human milk and dietary intake of fish and shellfish, which was established in the women from responses to a questionaire on food consumption habits. The results of this study of food products commonly consumed in Japan and the levels found in nursing women raises a concern about low level PBDE contamination of fish and other foods intended for human consumption. Further, high concentration of PBDEs hi the powder milk was also observed in the powder milk. Less