Comprehensive study of Buerger's Disease

伯格氏病的综合研究

• 批准号: 18390342
• 负责人: IWAI Takehisa
• 金额: $ 8.92万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390342/
• 关键词: oral bacteria; burger disease; atherosclerosis; porphyromanas gingivalis; platelet aggregation; HAL遺伝子; 歯周菌病

Weak oral bacteria represented by periodontal bacteria have been demonstrated from the various vascular lesions. Demonstrated regions are various; in the atheroma, thrombus of the occluded artery of Buerger disease, abdominal aortic aneurismal wall, and varicose veins. Serum titer levels are now available to study in each bacteria and have shown a significant relationship with severity and individual differences. It is estimated that lymph vessel openings catch the bacteria on the the pathway from the mouth to the blood stream and then carry them to the vein of the venous angle near the supraclavicular area. As for, periodontal bacteria, a typical one, P. gingivalis, activates the platelet strongly and make the platelets mass including bacteria inside without phagocytosis. At that time, cytokines and serotonin are discharged. Platelet engulfment was clearly demonstrated in the electron microscopy. An animal study using rats showed a small arterial thrombus formation after continuous intravenous infusion of the Pg bacteria for 2-4 weeks.

以牙周菌为代表的口腔弱菌已从各种血管病变中得到证实。示范区域多种多样;动脉粥样硬化、闭塞动脉血栓、腹主动脉瘤壁和静脉曲张。血清滴度水平现在可用于研究每种细菌，并已显示出与严重程度和个体差异的显着关系。据估计，淋巴管开口在从口腔到血流的路径上捕获细菌，然后将它们携带到锁骨上区域附近的静脉角静脉。而牙周细菌，其中典型的牙龈卟啉单胞菌，能强烈激活血小板，使血小板聚集成团，内含细菌而不被吞噬。此时，细胞因子和血清素被排出。电子显微镜检查清楚地显示血小板吞噬。使用大鼠进行的动物研究显示，在连续静脉输注Pg细菌2-4周后形成小动脉血栓。

项目成果

Elevated IgG titers to periodontal pathogens related to Buerger disease

• DOI: 10.1016/j.ijcard.2006.11.032
• 发表时间: 2007-10-01
• 期刊: INTERNATIONAL JOURNAL OF CARDIOLOGY
• 影响因子: 3.5
• 作者: Chen, Yi-Wen;Iwai, Takehisa;Ishikawa, Isao
• 通讯作者: Ishikawa, Isao

非高脂血症下肢閉塞性動脈硬化症に対するアフェレシス治療の他施設臨床評価

其他机构单采治疗非高脂血症下肢动脉硬化闭塞症的临床评价

• 发表时间: 2006
• 期刊: 日本アフェレシス学会雑誌 25
• 作者: 阿岸鉄三;岩井武尚;石丸 新;天野 泉;東 仲宣;非高脂血症下肢閉塞性動脈硬化症に対するアフェレシス治療研究会
• 通讯作者: 非高脂血症下肢閉塞性動脈硬化症に対するアフェレシス治療研究会

Anultrastructural study of Porphyromonas gingivalis-induced platelet aggregation.

牙龈卟啉单胞菌诱导的血小板聚集的超微结构研究。

• 发表时间: 2008
• 期刊: Thromb Res. (印刷中)
• 作者: Li X;Iwai T;Nakamura H;Inoue Y;Chen Y;Umeda M;Suzuki H.
• 通讯作者: Suzuki H.

Effect of low-density lipoprotein apheresis on patients with peripheral arterial disease. Peripheral arterial disease LDL apheresis multicenter study (P-LAS).

低密度脂蛋白单采术对周围动脉疾病患者的影响。

• 发表时间: 2006
• 期刊: Int Angio 25
• 作者: Tsuchida H;Shigematsu H;Ishimaru I;Iwai T;Akaba N;Umezu S
• 通讯作者: Umezu S

下肢のしびれ バージャー病

下肢麻木布尔格病

• 发表时间: 2006
• 期刊: 綜合臨床 55
• 作者: 工藤敏文;岩井武尚.
• 通讯作者: 岩井武尚.