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Development oforal health pedormance assessment system usingbreath, gingival crevicular fluid and saliva

利用呼吸、龈沟液和唾液的口腔健康表现评估系统的开发

基本信息

批准号：
18390568
负责人：
TANAKA Muneo
金额：
$ 10.3万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390568/
关键词：
oral health performance assessment lifestyle risk factor oral malodor nerindnntal disease salivary marker volatile organic compounds cluster analysis 臭気指数口腔保健要因歯周病細菌喫煙炎症マーカー

项目摘要

The objective of this study was to develop the oral health performance assessment system by clarification of association between oral malodor, periodontal disease progression. and biomarkers from breath air, gingival crevicular fluid and. saliva. Hydrogen sulfide, methyhmercaptan, ammonia, trimethylamine and butyraldehyde influenced total malodor intensity (MI) value. The clinical parameters, incruding tongue-coating score and plaque index were associated with total MI values. In the multiple logistic model, significant variables were current smoking and hours of sleep in lifestyle-related factors served as independent variables. Additionally, 38.5% of periodontal disease progression was attributable to current smoking. Moreover, pack-years of smoking demonstrated a dose-response relationship with disease progression. These results show that smoking exerted the greatest influence on periodontitis risk among lifestyle factors. Levels of salivary markers including prostaglandin F2, lactoferrin, albumin, aspartate aminotransferase, lactate dehydrogenase and alkaline phosphatase were significantly lower in current smokers. However, no meaningful differences in the proportions of six periodontal pathogens were observed between current and non-current smokers. Based on the malodor-intensity values of seven gases, the halitosis patients were classified into four clusters. These clusters showed different clinical characteristics. Furthermore, in multiple logistic regression analysis of "not improved outcome" as a dependent variable, only one of clusters showed independent association.

本研究的目的是通过阐明口腔恶臭，牙周疾病进展之间的关联，发展口腔健康性能评估系统。以及来自呼吸空气、龈沟液和。口水硫化氢、甲胺、氨、三甲胺和丁醛影响总恶臭强度（MI）值。舌苔评分、斑块指数等临床参数与总MI值相关。在多元Logistic模型中，显著变量为目前吸烟和睡眠时间的生活方式相关因素作为自变量。此外，38.5%的牙周病进展可归因于当前吸烟。此外，吸烟包年证明了与疾病进展的剂量反应关系。这些结果表明，在生活方式因素中，吸烟对牙周炎风险的影响最大。目前吸烟者的唾液标志物，包括前列腺素F2，乳铁蛋白，白蛋白，天冬氨酸转氨酶，乳酸脱氢酶和碱性磷酸酶的水平显着降低。然而，目前和非目前吸烟者之间没有观察到有意义的差异，在六个牙周病原体的比例。根据七种气体的恶臭强度值，将口臭患者分为四类。这些集群显示出不同的临床特征。此外，在以“未改善结局”作为因变量的多元Logistic回归分析中，只有一个聚类显示出独立关联。