Development of a New Type of Electronic Nose System Running on Artificial-intelligence Softwear

我们以前曾报道，在带有电子鼻的顶音模式下确定的分数提供了与口臭相关的客观测量，但通过多元线性回归方法获得的分数仅显示相对值，而不是绝对值。本研究的目的是临床评估呼吸空气中包括挥发性硫化物(VSCs)在内的九种挥发性有机化合物(VOCs)，并使用电子鼻(EN)系统评估临床口腔恶臭强度(以绝对值表示)。18名健康成人和23名恶臭患者使用感官测试结果、气相色谱VSCs浓度和代表每一系列VOCs与EN的恶臭强度的分数来评估。硫化氢和系列硫化物对感官评分的贡献率分别为21%和25%。此外，胺类和芳香类化合物对感官评分的影响分别为18%和8%。使用EN的VOSS总强度评分与感官评分之间的相关系数为0.76。这些结果表明，用EN评价各种VOSS的气味可以准确地评价口腔恶臭，用电子鼻表达绝对值的口腔恶臭强度可能有助于临床评估口腔恶臭。

We have previously reported that the score as determined under top-note mode with an electronic nose provides objective halitosis-related measurements, but those obtained by the multiple linear regression method show only relative and not absolute values. The objective of this investigation was to assess clinically nine series of volatile organic compounds(VOCs) including volatile sulfur compounds(VSCs) in breath air and to assess clinically oral malodor intensity expressed as an absolute value using electronic nose(EN) system. Eighteen healthy adults and 23 malodor patients were assessed using results of an organoleptic test, concentration of VSCs using gas chromatography and a score representing malodor strength of each series of VOCs with an EN. Contribution of hydrogen sulfide and series of sulfur compounds to organoleptic score revealed 21 and 25%, respectively. In addition, series of amine and aromatic compounds also affected 18 and 8%, respectively for organoleptic score. The correlation coefficient between total intensity scores of VOSs using EN and organoleptic scores was 0.76. These results suggest that odor assessment of various VOSs with EN may give accurate evaluation of oral malodor and oral malodor intensity expressed an absolute value using electronic nose may be useful for evaluating clinically oral malodor.