Asian Collaborative Study for Creation of GFR Estimation Equation (ACOS-CG-FREE)

创建 GFR 估计方程的亚洲合作研究 (ACOS-CG-FREE)

• 批准号: 18406032
• 负责人: MATSUO Seiichi
• 金额: $ 8.17万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18406032/
• 关键词: chronic kidney disease (CKD); glomerular filtration rate (GFR); GFR equation; inulin clearance; 糸球体濾過値(GFR); 国際情報交換; 韓国:中国

Glomerular filtration rate (GFR) Project by Japanease Society of Nephrology was carried among 80 collaborating centers all over Japan and new Japanese GFR equations were developed in 413 participants and validated in 350 participants. In our study, GFR was evaluated in 95 Japanese cases.Protocol of inulin clearance (Cin) was simplified in this study. In the standard method, GFR is evaluated by 3 sets of Cin for 30 minutes, which is not practical in clinical use. GFR evaluated with 2 consecutive Cin for 30 minutes was compared to those with 3 consecutive one in 737 cases. GFR by 2 consecutive Cin showed high correlation coefficients against GFR by 3 Cin tests (r=0.988). Root mean square error (RMSE) was 5.3 ml/min per 1.73 m^2. Therefore, GFR was evaluated by simplified Cin protocol with 2 consecutive Cin tests in this study.Doctor driven clinical trials of Cin tests were conducted in Korea and Taiwan. Using simplified Cin protocol, GFR was evaluated in 113 Korean and 200 Taiwanese cases and Japanse GFR equation was validated. All samples were assayed in a central laboratory in Japan. No severe adverse event by Cin test was reported. Accuracy within 30% of measured GFR was 74% for Japanese equation, which is greater than that of MDRD or Cockroft-Gault equation.In conclusion, Japanese GFR equation are more accurate for the Korean and Taiwanese population than the previously reported equations.

日本肾脏病学会肾小球滤过率（Glomerular filtration rate， GFR）项目在日本80个合作中心开展，在413名参与者中建立了新的日本GFR方程，并在350名参与者中进行了验证。在我们的研究中，我们评估了95例日本病例的GFR。本研究简化了菊粉清除（Cin）方案。在标准方法中，GFR是用3组Cin评价，时间为30分钟，在临床应用中并不实用。在737例中，比较连续2次注射30分钟的GFR与连续3次注射的GFR。3个试验结果表明，连续2个Cin的GFR与GFR呈高度相关（r=0.988）。均方根误差（RMSE）为5.3 ml/min / 1.73 m^2。因此，本研究采用简化的Cin方案，连续进行2次Cin试验来评估GFR。在韩国、台湾等地进行了医生主导的临床试验。采用简化的Cin方案，对113例韩国和200例台湾患者的GFR进行评估，并对日本的GFR方程进行验证。所有样本都在日本的一个中心实验室进行分析。Cin试验未见严重不良反应。日本方程测量GFR在30%以内的准确率为74%，高于MDRD或Cockroft-Gault方程。综上所述，日本的GFR方程比之前报道的方程更准确地适用于韩国和台湾人口。

项目成果

Cardiac Troponin T Predicts Long-Term Cardiovascular Morbidity and Mortality in chronic Kidney Disease Patients on Maintenance Hemodialysis.

心肌肌钙蛋白 T 可预测维持性血液透析的慢性肾病患者的长期心血管发病率和死亡率。

• 发表时间: 2007
• 作者: R.Ahlswede;et al.(eds.);分担執筆 H.Nagaoka 他;Schmid H.;Imai E.;Shoji T.;Imai E.;Kanamaru Y.;Yoshimichi Urahama;Kaoru Yasuda;Takenori Ozaki;Kaoru Yasuda;Enyu Imai;Yutaka Fujita;Shigejiro Iwashima
• 通讯作者: Shigejiro Iwashima

Estimation of Japanese CKD Population by a Modified MDER Equation

通过修正的 MDER 方程估算日本 CKD 人口

• 发表时间: 2006
• 作者: R.Ahlswede;et al.(eds.);分担執筆 H.Nagaoka 他;Schmid H.;Imai E.;Shoji T.;Imai E.;Kanamaru Y.;Yoshimichi Urahama;Kaoru Yasuda;Takenori Ozaki;Kaoru Yasuda;Enyu Imai;Yutaka Fujita;Shigejiro Iwashima;Tomoki Kosugi;Waichi Sato;Masaru Horio;Yutaka Fujita;Tomoki Kosugi;Enyu Imai;Tomoki Kosugi;Kaoru Yasuda;Yukio Yuzawa;Enyu Imai
• 通讯作者: Enyu Imai

Risedronate, an effective treatment for glucocorticoid-induced bone loss in CKD patients with or without concomitant active vitamin D (PRIUS-CKD)

• DOI: 10.1093/ndt/gfl567
• 发表时间: 2007-06-01
• 期刊: NEPHROLOGY DIALYSIS TRANSPLANTATION
• 影响因子: 6.1
• 作者: Fujii, Naohiko;Hamano, Takayuki;Ito, Takahito
• 通讯作者: Ito, Takahito

High Prevalence of Cardiac Valve Calcification and Its Association with Future Cardiovascular Morbidity and Mortality in End-Stage Renal Disease Patients at Beginnine of Hemodialysis Therapy.

终末期肾病患者在血液透析治疗开始时心脏瓣膜钙化的高发生率及其与未来心血管发病率和死亡率的关系。

• 发表时间: 2007
• 作者: R.Ahlswede;et al.(eds.);分担執筆 H.Nagaoka 他;Schmid H.;Imai E.;Shoji T.;Imai E.;Kanamaru Y.;Yoshimichi Urahama;Kaoru Yasuda;Takenori Ozaki;Kaoru Yasuda;Enyu Imai;Yutaka Fujita
• 通讯作者: Yutaka Fujita

High Prevalence of Cardiac Valve Calcification and Its Association with Future Cardiovascular Morbidity and Mortality in End-Stage Renal Disease Patients at Beginning of Hemodialysis Therapy.

终末期肾病患者在血液透析治疗开始时心脏瓣膜钙化的高发生率及其与未来心血管发病率和死亡率的关系。

• 发表时间: 2007
• 作者: R.Ahlswede;et al.(eds.);分担執筆 H.Nagaoka 他;Schmid H.;Imai E.;Shoji T.;Imai E.;Kanamaru Y.;Yoshimichi Urahama;Kaoru Yasuda;Takenori Ozaki;Kaoru Yasuda;Enyu Imai;Yutaka Fujita;Shigejiro Iwashima;Tomoki Kosugi;Waichi Sato;Masaru Horio;Yutaka Fujita
• 通讯作者: Yutaka Fujita